The work is based examination and treatment of 65 women of the premenopausal period. Assessment of daily blood pressure was carried out by the daily monitoring of blood pressure (DMBP); the state of central hemodynamics was studied by tetrapolar transthoracic rheography, the cerebral hemodynamics was studied by transcranial dopplerography (TCDH), a comprehensive assessment of the hemostasis system -by standard laboratory methods. "Dry" carbon dioxide baths are an effective method of treatment and rehabilitation of patients with a menopausal syndrome. They improve hemostasis, central and cerebral hemodynamics.
It has been established that, under the conditions of technogenic risk, the risk of the pathology of the gestation period increases, leading to the suffering of the fetus as a result of the development of placental insufficiency, an increase in perinatal losses and infant morbidity. The article presents facts about the features of the course of the gestation period, the status of fetuses and newborns under the influence of adverse environmental factors. The condition of the fetuses was determined on the basis of cardiotocography and ultrasound. In order to assess newborns, the cytokine profile and non-specific factors of body defense were studied. The positive dynamics of indicators of the state of the prenatal fetus was achieved on the inclusion in the complex of therapy of means that promote the elimination of heavy metal salts from the mother's body.
Aim. The aim of this work was to analyze recently published data on the risk factors and pathogenetic aspects of metabolic syndrome (MS) in women of reproductive age.Materials and methods. This review covers data presented in foreign and Russian literature, which has been published in electronic bibliographic databases Pubmed and the Cochrane Library over the past 10 years. Specifi cally, we carried out an analysis of works containing information on risk factors, pathogenetic aspects and diagnostic criteria of MS in women of reproductive age, as well as on methods currently used for the treatment of this condition.Results. We characterize modern theories that explain mechanisms triggering the development of MS complicated with diabetes 2 type and polycystic ovary syndrome (PCOS). Data on proteomic markers refl ecting the complex pathogenesis of PCOS is generalized, along with their role in the diagnosis and treatment of this disease. The possibility of using these markers for predicting pregnancy outcomes is shown. The importance of regulating metabolic processes for the preparation of women for pregnancy and fertility recovery is emphasized.Conclusion. Hyperandrogenism, insulin resistance, obesity, diabetes 2 type, dyslipidemia, PCOS are shown to be the most signifi cant factors determining pathological changes in fertile age women with metabolic syndrome. The correction of these factors should be included in the course of pregravid preparation for the prevention of adverse pregnancy outcomes.
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