25ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ ТО М L X I I В Ы П УС К 6 / 2 0 1 3 ■ В статье описана роль фолиевой кислоты при беременности, а также негативные последствия дефицита фолатов у беременных. На основе анализа собственных данных показано превышение нормы концентрации фолатов в крови беременных, принимающих препараты, содержащие фолиевую кислоту. Указаны возможные побочные эффекты длительного повышения в крови содержания фолиевой кислоты. Даны рекомендации по оптимизации фолатной терапии при осложнениях беременности.■ Ключевые слова: беременность; фолиевая кислота; гомоцистеин; витамин В 12 .
Modern data on the role of vitamin B12, and its biologically active form holotranscobalamin in particular, in the development of anemia of pregnancy are presented. Information on the vitamin B12 metabolism and its coupling with the folic acid and homocysteine metabolism is supplied. The new automated immunochemiluminescent method for the active vitamin B12 determination is described. Reference intervals for the holotranscobalamin and related indices that can be used for the differential diagnosis of anemia of pregnancy are specified.
Diagnostic and therapy monitoring prospectives and challenges with pregnant women of different gestational age have been analysed and reviewed. The advanced laboratory techniques for the prediction of preeclampsia and fetal growth restriction, as well as such biomarkers as placental growth factor, neutrophil gelatinase-associated lipocalin, holotranscobalamin, 25-hydroxyvitamin D, B-type natriuretic peptide and cardiac troponin I are discussed.).
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