Folate therapy optimization in complicated pregnancy

Керкешко, Г. О.; Олегович, Керкешко Глеб; Arutjunyan, А. V.; Вартанович, Арутюнян Александр; Arzhanova, Olga N.; Николаевна, Аржанова Ольга; Milyutina, Yu. P.; Павловна, Милютина Юлия

doi:10.17816/jowd62625-36

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…В органiзмi людини i тварин ФК не синтезується, її джерелом є їжа i нормальна флора кишечника. Бiологiчну активнiсть в органi-Клiнiчна ендокринологiя змi виконує не сама ФК, а її похiднi фолати, якi беруть участь у безлiчi обмiнних процесiв, є кофакторами багатьох ферментативних реакцiй синтезу амiнокислот, таких як, метiонiн, серин, глiцин, нуклеїнових кислот, пуринiв, пiримiдинiв, вiтамiнiв [10]. ФК опосередковано впливає на метаболiзм катехоламiнiв, сприяє утворенню серотонiну в головному мозку, тобто надає антидепресивну дiю.…”

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“…До теперiшнього часу не розробленi чiткi показання щодо рiзних доз ФК для корекцiї рiвня ГЦ. На думку деяких авторiв, слiд чiтко роздiляти два напрямки фармакотерапiї фолiєвою кислотою: профiлактичне, спрямоване на заповнення добової потреби (дози в 400-1000 мкг/добу) це так звана фiзiологiчна межа та високодозована вiтамiнотерапiя (дози 4-5 мг/добу i вище) [10,12].…”

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The Levels of Folic Acid and Homocysteine in the Blood of Women With Polycystic Ovary Syndrome and the Dynamics of These Indicators During of Folate Therapy

Arkhypkina

Karachentsev

Bondarenko

et al. 2016

PEP

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It were examined 70 young women with PCOS. It was established, that these patients have lower levels of folic acid than healthy women, 47 % — reduction below reference values of norms, 52.8 % — hyperhomocysteinemia. Folic acid treatment at a dose of 5 mg/day helped to normalize its levels for 12 week therapy at that at women with normal body weight normalization was faster. The concentration of homocysteine during treatment as high as indicators of healthy women at patients with normal weight for 12 weeks of therapy, and at patients with obesity — for 24 weeks. Determination in blood levels of folate and homocysteine should be included a comprehensive examination of this category of patients, particularly at the stage pregravid period.

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The Levels of Folic Acid and Homocysteine in the Blood of Women With Polycystic Ovary Syndrome and the Dynamics of These Indicators During of Folate Therapy

Arkhypkina

Karachentsev

Bondarenko

et al. 2016

PEP

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Optimization of pregravid preparation in patients with a history of pregnancy losses

Logutova¹,

Будыкина²,

Melnikov³

et al. 2017

Ross. vestn. akush.-ginekol.

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Улучшение исходов беременности у пациенток с акушерскими потерями в анамнезе является одной из приоритетных проблем современного акушерства. Эти пациентки подвергаются углубленному мультидисциплинарному обследованию для исключения анатомических, генетических, гормональных, инфекционных причин прерывания беременности с последующим назначением прегравидарной подготовки.

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Micronutrient status of pregnant women with fetal congenital malformations

Milyutina,

Shengelia,

Bespalova

et al. 2023

Journal of obstetrics and women's diseases

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BACKGROUND:Congenital malformations of the central nervous system have extremely severe consequences, which makes it important to study their development and diagnosis during embryogenesis. Therefore, particularly relevant are studies in the field of prevention of fetal сongenital malformations. AIM:The aim of this study was to assess the micronutrient status (vitamin D, serum and erythrocyte folic acid, vitamin B12) and homocysteine levels in women with induced abortion in the second trimester of pregnancy based on fetal indications (fetal сongenital malformations). MATERIALS AND METHODS:This prospective cohort study enrolled 53 women with induced abortion for medical reasons from the fetus in the second trimester of gestation. All pregnant women were divided into two groups. Group 1 included 28 individuals without an established chromosomal abnormality in the fetus: with fetal сongenital malformations and no neural tube defects (n= 16) or with fetal сongenital malformations and neural tube defects (n= 12). Group 2 consisted of 25 pregnant women with established chromosomal abnormalities in the fetus. RESULTS:In pregnant women with fetal сongenital malformations and neural tube defects, blood serum vitamin B12level correlated with erythrocyte folic acid level and was lower compared with women with fetal сongenital malformations and no neural tube defects (p 0.05). No significant differences were found for other parameters. In pregnant women with fetal сongenital malformations, homocysteine level did not differ from that in women with normal fetal development at this stage of pregnancy. Meanwhile, folic acid and vitamin B12levels in women with fetal сongenital malformations were lower compared with pregnant women without this pathology (p 0.001). CONCLUSIONS:The features of micronutrient status found in patients with fetal сongenital malformations, in particular with neural tube defects, and the relationships between its individual parameters indicate complex etiologies of these pathologies. The data obtained indicate the expediency of assessing one-carbon metabolic parameters in the mother not only during pregnancy, but also at the stage of preconception preparation, as well as the need for additional research related to adequate control of vitamin intake and assessment of methionine cycle gene polymorphism.

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Folate therapy optimization in complicated pregnancy

Cited by 3 publications

References 33 publications

The Levels of Folic Acid and Homocysteine in the Blood of Women With Polycystic Ovary Syndrome and the Dynamics of These Indicators During of Folate Therapy

The Levels of Folic Acid and Homocysteine in the Blood of Women With Polycystic Ovary Syndrome and the Dynamics of These Indicators During of Folate Therapy

Optimization of pregravid preparation in patients with a history of pregnancy losses

Micronutrient status of pregnant women with fetal congenital malformations

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