Optimization of pregravid preparation in patients with a history of pregnancy losses

Logutova, L. S.; Будыкина, Т. С.; Melnikov, A. P.; Chursina, Z. M.; Tariverdieva, E. A.

doi:10.17116/rosakush201717274-77

Cited by 3 publications

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Анемічний синдром обумовлений гемічною гіпоксією. Зміни при сидеропенічному синдромі більш тяжкі і пов'язані з тканинним дефіцитом заліза [5,10,14]. Проте, високий вміст заліза, дисбаланс його обміну в організмі людини, особливо у вагітних, реалізується тяжкими ускладненнями, в тому числі вродженими вадами розвитку, що в свою чергу підкреслює актуальність теми, що вивчається.…”

unclassified

Pathogenetic Substantiation of Correction of Iron Content in Women's Blood on the Stage of Preconceptional Preparation for Pregnancy

Руденко¹,

Міщенко²,

Головатюк-Юзефпольська³

et al. 2020

Scientific Digest of Association of Obstetricians and Gynecologists of Ukraine

View full text Add to dashboard Cite

unclassified

Pathogenetic Substantiation of Correction of Iron Content in Women's Blood on the Stage of Preconceptional Preparation for Pregnancy

Руденко¹,

Міщенко²,

Головатюк-Юзефпольська³

et al. 2020

Scientific Digest of Association of Obstetricians and Gynecologists of Ukraine

View full text Add to dashboard Cite

Pathogenetic substantiation of personified correction of folate cycle disorders using a complex with metapholine for the congenital malformations prevention

Руденко

Міщенко

2020

View full text Add to dashboard Cite

Congenital malformations are pathology with a multifactorial etiology. Among their many endogenous, exogenous factors and hereditary predisposition are important. In particular a decrease in follicular enzymes (MTHFR, MTR, MTRR) activity at the genetic level, as well as a deficiency of vitamins and vitamin-like compounds of group B.Objective: to provide a pathogenetic justification for personified correction of disorders in the folate cycle in biological parents preparing for pregnancy to prevent congenital malformations in their children by using folates containing metafolin (5-MTHF).Materials and methods. The study involved 75 women and 75 men (biological parents) who had children/fetuses with congenital malformations in previous pregnancies, and 75 newborn children of these couples. All of them used the proposed preconceptional preparation. Alleles of folate cycle enzyme genes (MTHFR, MTR, MTRR) were determined by polymerase chain reaction in blood and saliva.Results. A high frequency of polymorphism of the folate cycle enzyme genes was observed in men among subjects (father, mother, child). The indicator was 77.7% compared with 68.7% in mothers and 60.7% in their children. The frequency of homozygous alleles was highest in parents (men) – 19.6%, lower in mothers – 13.1% and in children – 12.7%. Result of heterozygous alleles decreased from children indicator (87.3%) to their mothers (86.7%) and parents (80.4%).Conclusions. Obtained results emphasize the practical importance for determining the alleles of the folate cycle enzyme genes (MTHFR, MTR, MTRR) at the stage of preconception preparation for pregnancy in biological parents and then in their newborn children from the standpoint of preventive medicine. Reduced activity of the corresponding enzymes pathogenetically explains the feasibility of using folate complexes containing active folate metafolin (5-MTHF) in order to prevent congenital malformations.

show abstract

The Practical Importance of Laboratory Test for Hereditary Predisposition to the Folate Cycle Violations

Міщенко¹,

Руденко²

2019

Scientific Digest of Association of Obstetricians and Gynecologists of Ukraine

View full text Add to dashboard Cite

Optimization of pregravid preparation in patients with a history of pregnancy losses

Cited by 3 publications

References 3 publications

Pathogenetic Substantiation of Correction of Iron Content in Women's Blood on the Stage of Preconceptional Preparation for Pregnancy

Pathogenetic Substantiation of Correction of Iron Content in Women's Blood on the Stage of Preconceptional Preparation for Pregnancy

Pathogenetic substantiation of personified correction of folate cycle disorders using a complex with metapholine for the congenital malformations prevention

The Practical Importance of Laboratory Test for Hereditary Predisposition to the Folate Cycle Violations

Contact Info

Product

Resources

About