The problem of developing a methodology for assessing the effectiveness of the class teacher’s educational activity and the possibility of its implementation in the context of an educational establishment has been getting more vital. The developed methodology for assessing the class teacher performance efficiency was tested on the basis of four educational establishments in Nizhny Novgorod, which are the clinical internship bases to train future teachers and class teachers at Minin University (Nizhny Novgorod), who were experts carrying out the examination of the methodology for assessing the performance efficiency according to the proposed indicators. The developed methodology for assessing the class teacher performance efficiency can be used in the practice of educational organizations to develop a system for assessing the encouragement of the class teacher performance, supervising his professional growth, developing individual trajectories of professional improvement, analytical conclusions, and expertise.
The study concerns the phenomenon of a “professional teacher”, its social status, personal qualities and competences within the historical context. The authors apply the integration of philosophical, psychological, historical-pedagogical and pedagogical knowledge as such to understand the modern model of a teacher. The historical context as a complex of social conditions of pedagogical insights, concepts and assumptions of an ideal teacher and its professional training formed methodological fundamentals of the study dealing with the image of a teacher of the past, present and future. To define the mission of a teacher within the society and its professional characteristics the study analyzes beliefs, activities and works of educators, scientists, classic teachers and modern representatives of pedagogical science and educational practice. Defining the phenomenon of a “teacher”, the authors consider it through the unique nature of professional activity, personal qualities, compliance to public expectations and demands.
<div>Abstract<p>Melanoma differentiation-associated gene-7/interleukin-24 (<i>mda</i>-7/IL-24) is a unique member of the <i>IL-10</i> gene family that induces cancer-selective growth suppression and apoptosis in a wide spectrum of human cancers in cell culture and animal models. Additionally, recent clinical trials confirm safety and document significant clinical activity of <i>mda</i>-7/IL-24 in patients with diverse solid cancers and melanomas. Despite intensive study the molecular basis of tumor-cell selectivity of <i>mda</i>-7/IL-24 is not well characterized. Using deletion analysis, a specific mutant of MDA-7/IL-24, M4, consisting of amino acids 104 to 206, is described that retains the cancer-specific growth-suppressive and apoptosis-inducing properties of the full-length protein. Employing rationally designed mutational analysis, we show that MDA-7/IL-24 and M4 physically interact with BiP/GRP78 through their C and F helices, localize in the endoplasmic reticulum, and activate p38 MAPK and <i>GADD</i> gene expression, culminating in cancer-selective apoptosis. These studies provide novel mechanistic insights into the discriminating antitumor activity of MDA-7/IL-24 by elucidating BiP/GRP78 as a defined intracellular target of action and present an unparalleled opportunity to develop improved therapeutic versions of this cancer-specific apoptosis-inducing cytokine. (Cancer Res 2006; 66(16): 8182-91)</p></div>
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