The levels of 17 cytokines in the follicular fluid were measured by multiplex proteome analysis at the peak of stimulated ovulation during the in vitro fertilization cycle. In patients with ineffective folliculogenesis, the concentrations of IL-2, IL-4, IL-7, and granulocytic CSF in the follicular fluid were significantly lower than in women with greater mean number of collected oocytes. It was shown that multicomponent cytokine deficit was associated with lower production of high quality oocytes and lower efficiency of fertilization of the resultant oocytes in vitro. The absence of pregnancy after in vitro fertilization cycle is associated with lower levels of IL-2, IL-4, IL-7, granulocytic CSF, and macrophagic inflammatory protein 1b in combination with elevated contents of IL-8 and IL-13. The results attest to an important role of cytokines in the regulation of oogenesis and in preparation of the endometrium to implantation of the embryo.
Резюме. С помощью метода ранговой корреляции по Спирману оценивали направленность и вы-раженность взаимосвязи между показателями морфологических нарушений сперматозоидов с уров-нем цитокинов в семенной плазме мужчин, находящихся в длительном бесплодном браке. Корре-ляционный анализ показал наличие значимой положительной связи между частотой встречаемости морфологически аномальных сперматозоидов с уровнем IL-1β, MIP-1β, G-CSF и отрицательной с содержанием IL-5, IL-10 в семенной плазме. В целом полученные результаты отражают участие ци-токинов в регуляции мужской фертильности. Modes of interaction between sperMatozoid abnorMalities and cytokines in seMinal plasMa froM infertile Malesabstract. Spearman rank correlation analysis was applied to assess some interrelations between morphological abnormalities of spermatozoids in males with long-term infertility, and cytokine levels in their seminal plasma. Such statistical analysis has revealed a significant positive correlation between prevalence of morphologically abnormal spermatozoids and the levels of IL-1β, MIP-1β, G-CSF, along with negative relationship with IL-5 and IL-10 contents in seminal fluid. The data are, generally, demonstrating participation of cytokines in regulation of male fertility.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.