Role of cytokines in the regulation of reproductive function

Ostanin, А. А.; Айзикович, Б. И.; Айзикович, И. В.; Kozhin, A Yu; Черных, Е. Р.

doi:10.1007/s10517-007-0021-2

Cited by 38 publications

(31 citation statements)

References 11 publications

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“…Here, we demonstrated that IL7 stimulates the proliferation of cumulus cells, providing additional evidence that timely oocyte secretion regulates cumulus cell function, and in turn, potentially improves its own developmental competence. It has been reported that a lower IL7 level in pooled follicular fluid samples is associated with lower egg/embryo quality and lower in vitro fertilization success rates (29). In the same vein, we have demonstrated that normally fertilized oocytes had significantly higher follicular levels of IL7 compared with those with no or abnormal fertilization in egg donors.…”

Section: Discussionsupporting

confidence: 82%

Dynamic secretion during meiotic reentry integrates the function of the oocyte and cumulus cells

Çakmak

Franciosi

Zamah

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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The differentiation of the female gamete into a developmentally competent oocyte relies on the protected environment of the ovarian follicle. The oocyte plays a key role in establishing this microenvironment by releasing paracrine factors that control the functions of surrounding somatic cells. Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are secreted during follicle growth and play pivotal roles in this local regulation. The current view is that the function of these secreted factors declines in the periovulatory period when the oocyte reenters the meiotic cell cycle. Here, we provide evidence that oocyte reentry into meiosis is instead associated with a shift in the pattern of secretion with a new set of bioactive molecules synthesized before ovulation. Using interleukin 7 (IL7) as a prototypic secreted factor, we show that its secretion is dependent on activation of mRNA translation in synchrony with the cell cycle and that its translation is under the control of somatic cells. IL7 is part of a local feedback loop with the soma because it regulates cumulus cell replication. Similar conclusions are reached when IL7 secretion is measured in human follicular fluid during in vitro fertilization cycles. IL7 concentration in the follicular fluid correlates with the oocyte ability to reach the MII stage of maturation. These findings are consistent with the hypothesis that a new set of local factors is secreted by the oocyte during ovulation. These dynamic secretions are likely critical for promoting the final stages of maturation and oocyte developmental competence.oocyte maturation | mRNA translation | oocyte secreted factors | interleukin-7

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Section: Discussionsupporting

confidence: 82%

Dynamic secretion during meiotic reentry integrates the function of the oocyte and cumulus cells

Çakmak

Franciosi

Zamah

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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“…for many interleukins (IL), tumour necrosis factor-␣ (TNF-␣), and granulocyte colony-stimulating factor (G-CSF). The correlations between IL-8 and IL-13 and the above biological endpoints were negative (Ostanin et al, 2007).…”

Section: Introductionmentioning

confidence: 91%

“…Reduced follicular fluid concentrations of some cytokines have been reported to be associated with successful IVF treatment cycles (Ostanin et al, 2007;Altun et al, 2011). It is possible that increased levels of some cytokines might impair the endometrial receptivity as no other differences were observed in either oocyte or follicular parameters.…”

Section: Serum (N=30) ->mentioning

confidence: 99%

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Serum but not follicular fluid cytokine levels are increased in stimulated versus natural cycle IVF: a multiplexed assay study

Bersinger

Kollmann

Wolff

2014

Journal of Reproductive Immunology

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“…It is evidenced that cytokines, as a result of local synthesis in the ovary and from blood plasma, are present in follicular fluid and modulate the processes of follicular growth [5], oocyte maturation [6], ovulation [7], steroidogenesis [8], embryo development, and pregnancy [9]. It is well established that an adequate vascular supply is essential for ovarian follicle development [10].…”

Section: Introductionmentioning

confidence: 99%

Intrafollicular interleukin-8, interleukin-12, and adrenomedullin are the promising prognostic markers of oocyte and embryo quality in women with endometriosis

Singh

Dutta

Chattopadhyay

et al. 2016

J Assist Reprod Genet

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Purpose The study aimed to investigate key intrafollicular prognostic factors among various cytokines and angiogenic molecules for prediction of mature oocytes and good-quality embryos in women with endometriosis undergoing in vitro fertilization (IVF). Methods Paired follicular fluid and serum samples were collected from 200 women with advanced stage endometriosis and 140 normal ovulating women during oocyte retrieval. The concentrations of cytokines (pro-inflammatory: IL-1β, TNF-α, IL-2, IL-8, IL-12, IFN-γ; anti-inflammatory: IL-4, IL-6, IL-10) and angiogenic molecules (vascular endothelial growth factor (VEGF), adrenomedullin, angiogenin) were determined in follicular fluid and serum using ELISA. Expression of these molecules was subjected to multivariate analysis for the identification of major predictive markers of oocyte and embryo quality. Receiver operating characteristic (ROC) curve was applied to determine the best cutoff point for the discrimination between mature and immature oocytes in these women. Results Significant increases in levels of cytokines and angiogenic molecules were observed in women with endometriosis compared to controls (P < 0.001). From the validated partial least squares-discriminant analysis (PLS-DA) model, IL-8, IL-12, and adrenomedullin were identified as the most important factors contributing to endometriosis and were negatively associated with oocyte maturity and embryo quality. Conclusion The levels of IL-8, IL-12, and adrenomedullin may be good indicators of embryo and oocyte quality in endometriosis patients undergoing IVF. Further studies are necessary to ascertain the potential of these markers for oocyte and embryo developmental competence which may help improve the chances of a successful IVF in endometriosis patients.

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Role of cytokines in the regulation of reproductive function

Cited by 38 publications

References 11 publications

Dynamic secretion during meiotic reentry integrates the function of the oocyte and cumulus cells

Dynamic secretion during meiotic reentry integrates the function of the oocyte and cumulus cells

Serum but not follicular fluid cytokine levels are increased in stimulated versus natural cycle IVF: a multiplexed assay study

Intrafollicular interleukin-8, interleukin-12, and adrenomedullin are the promising prognostic markers of oocyte and embryo quality in women with endometriosis

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