The article demonstrates the methodical approach to the justification of biomarkers of adverse effects (for example, endothelial dysfunction) in workers of sylvinite ore-dressing production occupied in conditions of the long-term noise exposure at the level of 85-95 dBA. The methodology testing revealed that the professional risk in workers of basic specialties is estimated from mild to unbearable by the criterion class of working conditions (3.1.-3.3.). Hypertensive heart disease is a most often occupationally conditioned disorder (RR = 8.69, DI = 2.53-29.83; etiological fraction (EF) = 88.49%). Endothelial dysfunction, pathogenetically related to the development of hypertension, has a high degree of occupational conditionality in terms of a reduced level of K-brachial artery sensitivity to stress and a reduced level of the relative increase in the brachial artery diameter. Biomarkers of endothelial dysfunction (in terms of reducing the relative increase in the brachial artery diameter) are elevated serum levels of TSH, MDA, IL-10, lipoprotein (a) in respect to the physiological norms. The reasonable biomarkers of negative effect allow to expand the evidence base of industrial conditioning of disease process in workers at individual and group level at the determined noise exposure.
Introduction. Preservation and growth of the country population is the top national priority in the Russian Federation. A contemporary approach focuses on several especially urgent demographic issues that can be resolved, among other things, due to public healthcare systems becoming more efficient. The present research work is vital due to the necessity to achieve target medical and demographic parameters fixed in the national and federal projects and regional programs. These parameters include life expectancy and mortality caused by cardiovascular and oncologic diseases. The goal of this work is a development of new approaches for the complex evaluation of potential management reserves of health population indicators and the prognosis of efficiency of targeted activities performed within public healthcare systems and aimed at increasing life expectancy through reducing mortality among the population caused by cardiovascular diseases and oncologic diseases. Material and methods. The work dwells on solving a “direct” task in the “medical activities - morbidity - mortality” triple analysis system; the solution involves predicting changes in morbidity and mortality under preset, planned, or scenario changes in parameters related to the public healthcare system. We modelled cause-and-effect relations in the above system, applying mathematical statistics techniques (correlation-regression analysis and factor analysis) with the consequent medical expertise of obtained results. Results. These procedures allow assessing health losses and spot out priorities in activities performed within the public healthcare system as well as ranking managerial decisions, already taken or only planned, as per their efficiency, taking into account territories; sex and age structure of the population; diseases, their subclasses and gravity; specific activities performed within the public healthcare system (prevention, diagnostics, or treatment). We should stress that the most significant potential management reserves of reducing mortality are achieved on territories with maximum mortality levels due to reserves for the reduction in it; these reserves are manageable due to prevention and early diagnostics. Conclusion. Research techniques and results described in the present work can be used in practice to achieve target parameters fixed by national and regional priorities and to select an optimal set of activities aimed at reducing mortality among the population.
Вопросы взаимоотношения науки и богословия являются одними из наиболее интересных в области христианской апологетики. Одним из ярких христианских апологетов является С. Мейер, доктор философии (PhD) Кембриджского университета в области истории и философии науки и активный сторонник так называемой «теории разумного замысла» (ID). Первые книги С. Мейера «Подпись в клетках» и «Сомнение Дарвина» вызвали широкий общественный резонанс и привлекли внимание большого круга учёных в различных отраслях научного знания. Острота дискуссий после публикации книг была столь сильной, что С. Мейер предпринял очередную попытку детально объяснить свои взгляды в своей новой книге «Возвращение к гипотезе Бога: три научных открытия, которые открывают Разум за Вселенной». Эта книга представляет собой наиболее всеохватное, строгое и доступное для прочтения изложение концепции замысла в области космологии и биологии.
The relationship between science and theology is one of the most interesting issues in the field of Christian apologetics. One of the brightest Christian apologists is S. Meyer, a Doctor of Philosophy (PhD) from Cambridge University in the history and philosophy of science and an active proponent of the so-called "Intelligent Design Theory" (ID). The first books of S. Meyer "Signature in Cells" and "The Doubt of Darwin" caused a wide public response and attracted the attention of a large number of scientists in various fields of scientific knowledge. So intense was the discussion after the books were published that S. Meyer made another attempt to explain his views in detail in his new book, The Return to God Hypothesis: Three Scientific Discoveries that Reveal the Mind Behind the Universe. This book is the most inclusive, rigorous and readable account of the concept of design in cosmology and biology.
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