Abstract. Results of current study have shown that acute brucellosis is characterized by increase of T-helper and cytotoxic T-lymphocytes and decrease of phagocytic activity of neutrophyls in the blood. In patients with chronic form of disease the decline of T-helper and cytotoxic T-lymphocytes together with activation of humoral immunity and increasing of B-lymphocytes and levels of immunoglobulins A and G have been observed. Thus, revealed changes indicating the formation of secondary immunodeficiency in chronic disease course. Results of the study confirmed the needs for a permanent immunological monitoring of patients with brucellosis as well as conducting a comprehensive immunological testing of patients to develop the individual scheme of corrective therapy.
We studied the dependence of climatotherapy effectiveness in patients with chronic heart failure (functional classes 0-II) on Ca(2+)-ATPase, phospholamban, beta1-adrenoceptor, and insulin-like growth factor 1 gene polymorphisms and possible interaction of these genes during the realization of the effect of climatotherapy. The effectiveness of climatotherapy depended on polymorphism of the studied genes; the maximum effect was attained in patients with the GG polymorphism of the Ca(2+)-ATPase gene, GT polymorphism of the phospholamban gene, ArgGly polymorphism of the beta1-adrenoceptor gene, and 19/19 polymorphism of the insulin-like growth factor 1 gene. We demonstrated additive interaction of Ca(2+)-ATPase and beta1-adrenoceptor genes during the realization of the cardiotonic effect of climatotherapy.
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