Genetic determinants of the efficiency of climatotherapy in patients with chronic heart failure

Abstract

We studied the dependence of climatotherapy effectiveness in patients with chronic heart failure (functional classes 0-II) on Ca(2+)-ATPase, phospholamban, beta1-adrenoceptor, and insulin-like growth factor 1 gene polymorphisms and possible interaction of these genes during the realization of the effect of climatotherapy. The effectiveness of climatotherapy depended on polymorphism of the studied genes; the maximum effect was attained in patients with the GG polymorphism of the Ca(2+)-ATPase gene, GT polymorphism of the phospholamban gene, ArgGly polymorphism of the beta1-adrenoceptor gene, and 19/19 polymorphism of the insulin-like growth factor 1 gene. We demonstrated additive interaction of Ca(2+)-ATPase and beta1-adrenoceptor genes during the realization of the cardiotonic effect of climatotherapy.

The Human G147D-Protein Phosphatase 1 Inhibitor-1 Polymorphism Is Not Associated with Altered Clinical Characteristics in Heart Failure

“…Indeed, an increasing number of polymorphisms and mutations in signaling components regulating cardiac contractile function have been found to be linked to dilated cardiomyopathy or propensity to arrhythmias [17,18,19,20,21]. For example, multiple human polymorphisms on adrenergic signaling pathways have been reported to be direct or conjunct factors affecting development, prognosis or therapy of heart failure [17,22,23,24,25]. PP1 inhibitor-1 has recently emerged as an important regulator for cardiac contractile function by maintaining an appropriate phosphorylation level of cardiac proteins and serving as a downstream mediator in the β-adrenergic signaling pathway.…”

The application of climatic therapy in the health resorts of the Black Sea coast of the Caucasus: the current state-of-the-art and the prospects for the further development

“…Разработаны мето-ды расчета биоклиматических показателей и их рай-онирования, физиологические принципы санитар-но-климатического районирования территорий, са-наторно-курортной реабилитации населения, ис-следованы проблемы акклиматизации населения в различных климатических условиях, механизмы физиологического и лечебного воздействия климата и погоды на организм человека и его жизнеобеспе-чение [21,22]. Проведенные в различных климати-ческих зонах России исследования по адаптации организма человека к неблагоприятным условиям среды позволили разработать систему расчета и оценки погодных условий с учетом сезонных коле-баний и изменчивости основных гелиометеороло-гических факторов.…”

A proposal for a worldwide definition of health resort medicine, balneology, medical hydrology and climatology

“…Moreover, randomised controlled studies on clinical effects (Schuh 1993;de Andrade et al 2008;Harari et al 2007;Hodak et al 2003;Wolf et al 2003b;Cohen et al 2005;Autio et al 2002) and relevant factors (Cohen et al 2008;Uosif et al 2008;Kovlen et al 2007;Nissen et al 1998) are available within this area. For treatment in specific climatic regions, scientific studies have shown beneficial effects in various health conditions (Kragballe et al 1996;Gutenbrunner et al 2007;Sukenik et al 1990aSukenik et al , 1990bSukenik et al , 1994Sukenik et al , 1995Paran et al 1998;Sukenik 1998;Buskila et al 2001;Neumann et al 2001) Use of other therapeutic factors A description of the use of other therapeutic factors is beyond the framework of this paper.…”