Experience with fractional photothermolysis in the therapy of gra-nuloma annulare

Харчилава, М. Г.; Пономаренко, Г Н; Plakhov, V.N.; Хайрутдинов, В. Р.; Белоусова, И. Э.; Самцов, А. В.; Sokolovsky, E. V.

doi:10.17116/kurort20199603160

Cited by 1 publication

(5 citation statements)

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“…After title and abstract screening of 452 articles and full‐text review of 45 articles, 31 articles were ultimately included in our review (Figure 1). 10‐45 Two studies of which were conference abstracts and five not in the English language. Studies were published between 1988 and 2020 and included 31 case series (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen studies reported on PUVA therapy in patients with GA (Table ), representing a pooled sample size of 131 patients, with a mean age of 60.5 years (6–89) and available data showed 76% ( n = 80/105) were female 10,11,22,25,27,29,30,32‐37 . Overall, PUVA showed complete response in 59% ( n = 77/131) of patients with GA in mean 2.1 months, partial response in 25% (n = 33/131) in mean 2.2 months, and no response in 16% ( n = 21/131) (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Ten studies included in this review reported on UVA1 phototherapy in patients with GA (Table ), representing a sample size of 89 patients, with mean age of 61.1 years (45–74) and 78% ( n = 45/58) were females 17‐23,33,36,37,46‐48 . Available data demonstrate that UVA1 led to complete response in 31% (n = 27/86) of patients within mean of 0.8 months, partial response in 36% ( n = 31/86) within mean of 0.8 months, and no response in 33% ( n = 28/86) (Table 1, Figure 2).…”

Section: Resultsmentioning

confidence: 99%

“…Nine studies 27,28,32‐37 reported on UVB, nbUVB, and/or excimer laser therapy in patients with GA (Table ), representing a pooled sample size of 47 patients, with mean age 53.0 years (30–86), and available data showed that 78% ( n = 25/32) were female. Overall, UVB/nbUVB/excimer laser showed complete response in 40% ( n = 19/47) of patients with GA in mean 3.1 months, partial response in 26% ( n = 12/47) in mean 2.4 months, and no response in 34% ( n = 16/47) (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Two studies included in this review reported on laser‐ and energy‐based treatments in patients with GA (Table ), representing a pooled sample of 41 patients, with mean age 36.2 years ranging from 19 to 66, and 76% ( n = 31/41) females 29,37 …”

Section: Resultsmentioning

confidence: 99%

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Light‐ and laser‐based treatments for granuloma annulare: A systematic review

Mukovozov

Kashetsky

Richer

2021

Photoderm Photoimm Photomed

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Background: Granuloma annulare (GA) is challenging to treat, especially when generalized. A systematic review to support the use of light-and laser-based treatments for GA is lacking. Methods:We performed a systematic review by searching Cochrane, MEDLINE, and Embase. Title, abstract, full-text screening, and data extraction were done in duplicate. Quality appraisal was performed using the Joanna Briggs Institute critical appraisal tool for case series.Results: Thirty-one case series met the inclusion criteria, representing a total of 336 patients. Overall, psoralen ultraviolet light A (PUVA) showed the greatest frequency of cases with complete response (59%, n = 77/131), followed by photodynamic therapy (PDT) (52%, n = 13/25), ultraviolet light B (UVB)/narrowband UVB (nbUVB)/excimer laser (40%, n = 19/47), UVA1 (31%, n = 27/86), and lasers (29%, n = 8/28). Overall across treatment modalities, higher response rates were seen in localized GA compared to generalized GA. Conclusions:The body of evidence for light-and laser-based treatment of GA is sparse. Our results suggest that PUVA has a high clearance rate for GA but its use may be limited by concerns of carcinogenesis. Although PDT has the second highest clearance rate, adverse effects, small sample sizes, impractical treatment delivery (especially with generalized disease), and long-term concerns of carcinogenesis may limit its use. Although UVB/nbUVB/excimer laser appeared slightly less effective than other light therapies, we recommend UVB/nbUVB/excimer laser therapy as a first-line treatment for patients with generalized GA given wider availability and a favorable long-term safety profile.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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