Clinical morphological efficiency of local application of a new biopolymeric film was studied. The film was based on methylcellulose derivatives and contained shikonin (preparation of plant origin) and its esters isolated from Lithospermum erythrorhizon L. cell culture. Combined therapy of 30 patients (34-72 years) with erosive ulcerative lichen planus and leukoplakia of the buccal mucosa was carried out. Local application of the new drug led to more rapid pain relief, epithelialization of the inflammatory destructive foci in the buccal mucosa, and reduced the intensity of morphological signs of lesions in the studied patient population.
Tobacco smoking causes pronounced structural reorganization of the gingival mucosa and its atrophic changes. Odontopreparation stimulates destructive processes in the gingival mucosa promoting activation of local immunity (stimulation of immunoglobulin synthesis). Significant differences in the local humoral immunity (IgG dysimmunoglobulinemia) and cytokine spectrum in nonsmoking and tobacco-smoking patients were detected. Subcompensated level of immune resistance in tobacco smokers prompts referring them to a group at a high risk of chronic pathological processes of the oral cavity.
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