927 patients suffering from myasthenia gravis have been examined. A long-term follow-up analysis of the various forms of myasthenia in its clinical and neurological development has been conducted. Systematization and evaluation of the results have revealed major and frequent diagnostics criteria appropriate of myasthenia gravis. There are fatigable muscular weakness (92,3%), formula motor dis- turbances (91,9%), test with neostigmine (77,5%), generalized muscular weakness (76,3%), “flutter” and «migration» of the symptoms (71,1%), preservation of eye movements downward while it restricts in other directions (68,3%), combination ptosis and lagophthalmos on one side (50,1%). A diagram of clinical diagnostic, which help us to review a patient diagnosis of myasthenia gravis or suspect this exact disease has been developed.
The experience of recovery and rehabilitation of patients with hereditary neuromuscular diseases (more than 1000 observations) is generalized. Their own methods of pathogenetic and correcting therapy as well as patented methods are described. Their therapeutic efficacy is estimated on evidence of clinical observations, biochemical and electrophysiologic examinations. The possibility to obtain the stable and relatively prolonged remissions and to bring the disease under control is shown.
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