Clinical and immunological features and treatment of myasthenia gravis in the elderly (review)

Алексеева, Т. М.; Косачев, В Д; Халмурзина, А. Н.

doi:10.17650/2222-8721-2016-6-3-10-16

Cited by 5 publications

(8 citation statements)

References 23 publications

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“…Thus, the pathology of the thymus is found, practically, in every 4 patients. These data are fully consistent with Russian and foreign studies [7,10]. The data are presented in Table 4.…”

supporting

confidence: 92%

“…The lesion of lingopharyngeal musculature was observed in 44 % patients. The clinical manifestations of the generalized myasthenia gravis in patients residing in the Krasnodar Territory are correlated with the data of Russian and foreign authors [9,10]. The predominance of generalized form of myasthenia gravis is noted by the majority of myasthenia gravis researchers [1,7,9].…”

mentioning

confidence: 58%

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Clinical peculiarities of myasthenia gravis in Krasnodar region

Anatolevna¹,

Vladimirovna²,

Valerievna³

et al. 2018

Medical news of the North Caucasus

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Conclusions. Defined have been the major internal epidemiological threats to the entities involved in FWC-2018. Advance, forehand assessment of risks allowed for carrying out targeted and effective complex of prophylactic activities. Sanitary-epidemiological welfare of the participants, guests of the sports event was provided despite the coincidence of FWC-2018 terms with the period of seasonal morbidity rate increase as regards endemic, natural-focal infectious diseases of bacterial and viral etiology.

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“…Thus, the pathology of the thymus is found, practically, in every 4 patients. These data are fully consistent with Russian and foreign studies [7,10]. The data are presented in Table 4.…”

supporting

confidence: 92%

mentioning

confidence: 58%

Clinical peculiarities of myasthenia gravis in Krasnodar region

Anatolevna¹,

Vladimirovna²,

Valerievna³

et al. 2018

Medical news of the North Caucasus

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“…Education status was defined as the highest degree attained (primary school, college school, university). The diagnosis of MG was based on a typical clinical manifestation and confirmed by the positivity of at least one of the following [25,26]: demonstration of a pathognomonic decrement in repetitive nerve stimulation, a positive response of the muscular weakness to the edrophonium test and/or to the subsequent pharmacological treatment, and detection of MG-specific antibodies such as anti-acetylcholine receptor (AChR) antibodies or striational antibodies, i.e. antibodies directed against intracellular proteins of striated muscles (titin, actin, myosin, ryanodine receptors) [27].…”

Section: Study Populationmentioning

confidence: 99%

Depression in myasthenia gravis: a heterogeneous and intriguing entity

et al. 2020

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BACKGROUND Depressive symptoms in myasthenia gravis (MG) are common, may mimic other disease features, and contribute to misdiagnosis and diagnostic delay. Nevertheless, the clinical determinants of depressive symptoms in MG remain poorly studied, in particular their overlap with fatigue. Moreover, studies in MG have rarely looked at distinct depression phenotypes. METHODS In 68 consecutive MG patients, we ascertained cognitive-affective and somatic depression with the Beck Depression Inventory (BDI), and also assessed age at disease onset, education, marital state, work ability, sleepiness, fatigue, and treatment modalities. Disease severity was graded according to the Myasthenia Gravis Foundation of America (MGFA) classification. RESULTS The prevalence of moderate-severe depression was 20.5%. While depression and fatigue showed large overlap (n = 37, 54.4%), only fatigue increased with disease severity, while BDI scores did not. Thymectomy was independently associated with lower BDI scores, but had no impact on fatigue. Total BDI scores were similar in patients with predominantly cognitive-affective and with predominantly somatic depression. However, ESS correlated only with cognitive-affective BDI, and younger age was independently associated with cognitive-affective BDI. Conversely, female sex and thymectomy were independently associated with somatic BDI. CON-CLUSIONS Depression and fatigue are highly prevalent and largely overlapping comorbidities in MG, but only fatigue increased with disease severity, and only depression was milder in thymectomized patients. Comparative use of BDI subscales in MG reveals distinct depression phenotypes with distinct correlations to other disease features.

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“…Другой значимой особенностью нарушения нервно-мышечного проведения при миастении является чувствительность к температурным изменениям. Локальное согревание мышцы на 7-9 градусов приводит к нарастанию декремента на 10% при стимуляции частотой 3 имп/с [17]. Одной из предполагаемых причин преимущественного поражения проксимальных групп мышц по сравнению с дистальными мышцами является их бoлее высoкая внутримышечная температура [18].…”

Section: декремент-тестunclassified

Diagnostic Possibilities of Researching the State of Neuromuscular Transmission in Patients With Myasthenia and Myasthenic Sindromes

Валерьевна¹,

Заболотских²,

Хатхе³

et al. 2018

Kuban. nauсh. med. vestnik

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АННОТАЦИЯ Цель. Изучить и проанализировать диагностическую значимость различных электромиографических методов, применяемых для выявления нарушений нервно-мышечной передачи. Материалы и методы. Существует много методов исследования состояния нервно-мышечной передачи, каждый из которых несёт определённую диагностическую значимость, позволяющую определить характер поражения нервно-мышечного синапса, выявить механизмы его развития не только в клинически поражённых, но и интактных мышцах, а также на ранних стадиях заболевания, при локальных формах миастении. Исследование состояния нервно-мышечной передачи выполнялось с применением следующих электромиографических методик: стимуляционная электронейромиография (ЭНМГ), декремент-тест, джиттер-феномен. Результаты. Результатом анализа электромиографических диагностических методов исследования состояния нервно-мышечнoй передачи является оптимизация клинико-инструментального алгоритма обследования пациентов с миастенией и миастеническими синдромами. Заключение. Различные нейрофизиологические методы изучения состояния нервно-мышечной передачи несут определенную диагностическую значимость. Показаны преимущества отдельных электромиографических методов: исследование исходной амплитуды М-ответа, декремент-теста, джиттер-феномена. Подробно проанализированы показатели ЭНМГ-тестов, а также их изменения при нарушении нервно-мышечной передачи у пациентов с миастенией и миастеническими синдромами.

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Clinical and immunological features and treatment of myasthenia gravis in the elderly (review)

Cited by 5 publications

References 23 publications

Clinical peculiarities of myasthenia gravis in Krasnodar region

Clinical peculiarities of myasthenia gravis in Krasnodar region

Depression in myasthenia gravis: a heterogeneous and intriguing entity

Diagnostic Possibilities of Researching the State of Neuromuscular Transmission in Patients With Myasthenia and Myasthenic Sindromes

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