In the article the basic directions of development of innovative activity at mega- and microlevels are considered. The key tasks of scientific and technical policy have been studied with the purpose of determining the most effective innovation strategy that allows introducing the latest technologies into production. The main means for successful development of an enterprise in uncertain and rapidly changing environmental conditions is an effective integrated approach that ensures the formation and implementation of such an innovative activity option that will ensure the best results in the current situation. In these conditions, along with the important role of the production, resource and technological potential of the enterprise, the synergetic effect becomes crucial. The proposed methodology for determining the synergistic effect will link the directions of development of innovation activity using four groups of indicators (equipment, technology, management, sales). It is universal by definition not only of certain directions and projects at the enterprise level, but can be used at the level of the region and the country.
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