The subject of this study is the organizational and economic relations arising in the process of interaction of virtual companies with the companies manufacturing technically sophisticated products. Using the research results, the mechanism of interaction of virtual companies with public and private companies on the basis of public-private partnership when creating joint ventures for the production of innovative products is substantiated. The purpose of this article is to justify the mechanism of interaction of virtual companies with public and private companies on the basis of public-private partnerships. As a result of the research, the following tasks were solved: the stages of creating a virtual company were identified, the need for specialists for the creation and functioning of virtual companies was identified, a mechanism for the interaction of a virtual company with public and private companies on the basis of public-private partnerships was formed. Interaction of virtual and public and private companies on the basis of public-private partnership was revealed, providing mutual compensation of their shortcomings and strengthening of advantages, the manifestation of the synergy effect by attracting advanced competencies of individual firms, creative teams, and individuals.