Relevance: Breast cancer is one of the most common malignancies with a high mortality rate all over the world, including Kazakhstan. Despite modern advanced diagnosis and treatment methods, breast cancer remains one of the top three «killer cancers.» Treatment with immunoglobulins and modern targeted chemotherapy agents is efficient but does not reduce the breast cancer incidence. High treatment cost, antitumor drug resistance occurring during therapy, and significant side effects of chemotherapy urge the importance of prophylactic actions able to prevent the tumor disease. Purpose: To review the Vitamin D3 role and potential in breast cancer prevention. Results: The analysis of the literature reviews and original articles accessing the Vitamin D3 role in breast cancer pathogenesis and the study of the main antitumor mechanisms of Vitamin D3 action emphasize the need for large randomized prospective studies to determine the actual Vitamin D3 role in breast cancer pathogenesis and its possible inclusion in antitumor therapy regimens. Conclusion: The results obtained evidence the Vitamin D3 adjuvant potential in breast cancer treatment
В 2018 году в Республике Казахстан было зарегистрировано 4648 новых случая рака молочной железы (РМЖ). Результаты: О взаимосвязи уровня витамина Д3 и риска развития РМЖ свидетельствуют результаты достаточного числа исследований. Женщины с высоким содержанием витамина Д в рационе питания имеют меньший риск развития РМЖ. Положительное противоопухолевое действие витамина Д3 связано с двумя основными механизмами: антипролиферативным эффектом, ингибирующим ростом клеток путем подавления сигналов, стимулирующих рост рецепторов, которые имеются в ткани молочной железы, и проапоптотическим эффектом, способствующим естественной гибели клеток молочной железы. Заключение: Накопленные к настоящему времени данные о роли витамина Д3 в организме человека, взаимосвязи его уровня с развитием и течением онкологической патологии позволяют предположить, что коррекция недостаточного уровня витамина Д3 может быть перспективным направлением в профилактике и комплексном лечении онкологических заболеваний. Introduction: In 2018, 4648 new cases of breast cancer (BC) were registered in the Republic of Kazakhstan. Results: The relationship between the level of vitamin D3 and the risk of developing breast cancer is evidenced by the results of a sufficient number of studies. Women with a high vitamin D diet have a lower risk of developing breast cancer. The positive antitumor effect of vitamin D3 is associated with two main mechanisms: the antiproliferative effect, which inhibits cell growth by suppressing signals that stimulate the growth of receptors present in the breast tissue, and the proapoptotic effect, which promotes the natural death of breast cells. Conclusion: The data accumulated to date on the role of vitamin D3 in the human body, the relationship of its level with the development and course of oncological pathology suggests that the correction of insufficient levels of vitamin D3 may be a promising direction in the prevention and complex treatment of cancer.
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