The role of Vitamin D3 in breast cancer prevention: A literature review

Abstract

Relevance: Breast cancer is one of the most common
 malignancies with a high mortality rate all over the world,
 including Kazakhstan. Despite modern advanced diagnosis and treatment methods, breast cancer remains one of the top three «killer cancers.» Treatment with immunoglobulins and modern targeted chemotherapy agents is efficient but does not reduce the breast cancer incidence.
 High treatment cost, antitumor drug resistance occurring
 during therapy, and significant side effects of chemotherapy urge the importance of prophylactic actions able to prevent the tumor disease.
 Purpose: To review the Vitamin D3 role and potential
 in breast cancer prevention.
 Results: The analysis of the literature reviews and
 original articles accessing the Vitamin D3 role in breast
 cancer pathogenesis and the study of the main antitumor
 mechanisms of Vitamin D3 action emphasize the need
 for large randomized prospective studies to determine
 the actual Vitamin D3 role in breast cancer pathogenesis
 and its possible inclusion in antitumor therapy regimens.
 Conclusion: The results obtained evidence the Vitamin D3 adjuvant potential in breast cancer treatment