To enhance the penetration of oligonucleotide ("oligo') into cells, the &go was combined with the hydrophobic undccyl residue. Using the 'DNAsynthesator', we synthesized oligo, complementary to the loop-forming site of the RNA, encoding polymerase 3 of the iniluenza virus (type A), and comb&d it with the undecyl residue added to the 5' terminal phosphate group. It was found that the modified oligo effectively suppresses the influenza AIPR8j34 (HINI) virus reproduction and inhibits the synthesis of virus-specific proteins in MDCK cells. Under the same conditions, the non-modified antisense otigo and modified nonsense oligo did not affect the virus development.

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