To enhance the penetration of oligonucleotide ("oligo') into cells, the &go was combined with the hydrophobic undccyl residue. Using the 'DNAsynthesator', we synthesized oligo, complementary to the loop-forming site of the RNA, encoding polymerase 3 of the iniluenza virus (type A), and comb&d it with the undecyl residue added to the 5' terminal phosphate group. It was found that the modified oligo effectively suppresses the influenza AIPR8j34 (HINI) virus reproduction and inhibits the synthesis of virus-specific proteins in MDCK cells. Under the same conditions, the non-modified antisense otigo and modified nonsense oligo did not affect the virus development.

Passive and active acoustic measurements are effective and unique approaches to ocean observation. Both approaches have techniques that are well-established and suitable for immediate deployment as part of an operational observing system.Many of these techniques exploit the remarkable ability of lowfrequency sounds to traverse great distances in the ocean. Passive acoustic measurements of natural or man-made sounds are made for diverse purposes ranging from assessing the environmental impact of human activities, to geophysics, to monitoring changes in biodiversity in response to climate change. Active acoustic systems are employed for tracking instruments and acoustic tomography. Tomography has a role in the ocean observing system that is complementary to altimetry and profiling floats, particularly in the context of data assimilation and ocean modeling. Modest systems of acoustic receivers and sources deployed across ocean basins can make cost effective, sustained observations of a variety of ocean processes.

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This study suggests that P85 formulations do not interfere with the transport of glucose. This is, probably, due to compensatory mechanisms in the BBB. Regarding the transport of monocarboxylates, P85 formulations might slightly affect their homeostasis in the brain, however, without any significant toxic effects.