Image-guided phototherapy is considered to be a prospective technique for cancer treatment because it can provide both oncotherapy and bioimaging, thus achieving an optimized therapeutic efficacy and higher treatment accuracy. Compared to complicated systems with multiple components, using a single material for this multifunctional purpose is preferable. In this work, we strategically fabricated poly(acrylic acid)- (PAA-) coated Cu(OH)PO quantum dots [denoted as Cu(OH)PO@PAA QDs], which exhibit a strong near-infrared photoabsorption ability. As a result, an excellent photothermal conversion ability and the photoactivated formation of reactive oxygen species could be realized upon NIR irradiation, concurrently meeting the basic requirements for photothermal and photodynamic therapies. Moreover, phototherapeutic investigations on both cervical cancer cells in vitro and solid tumors of an in vivo mice model illustrated the effective antitumor effects of Cu(OH)PO@PAA upon 1064-nm laser irradiation, with no detectable lesions in major organs during treatment. Meanwhile, Cu(OH)PO@PAA is also an exogenous contrast for photoacoustic tomography (PAT) imaging to depict tumors under NIR irradiation. In brief, the Cu(OH)PO@PAA QDs prepared in this work are expected to serve as a multifunctional theranostic platform.
In order to investigate the basic mechanical properties and stress strain relationship model for bamboo scrimber manufactured based on a new technique, a large quantities of experiments have been carried out. Based on the analysis of the test results, the following conclusions can be drawn. Two main typical failure modes were classified for bamboo scrimber specimens both under tension parallel to grain and tension perpendicular to grain. Brittle failure happened for all tensile tests. The slope values for the elastic stages have bigger discreteness compared with those for the specimens under tensile parallel to grain. The failure modes for bamboo scrimber specimens under compression parallel to grain could be divided into four. Only one main failure mode happened both for the bending specimens and the shear specimens. With the COV values of 28.64 and 25.72 respectively, the values for the strength and elastic modulus under tensile perpendicular to grain have the largest discreteness for bamboo scrimber. From the point of CHV values, the relationship among the mechanical parameters for bamboo scrimber were proposed based on the test results. Compared with other green building materials, bamboo scrimber manufactured based on a new technique has better mechanical performance and could be used in construction area. Three stress strain relationship models which are four-linear model, quadratic function model, and cubic function model were proposed for bamboo scrimber specimens manufactured based on a new technique. The latter two models gives better prediction for stress strain relationship in elastic plastic stage.
In order to investigate the influence of length and compression directions upon behaviour of parallel bamboo strand lumber (PBSL) specimens, 240 axial compression tests have been performed. With three similar one different typical failure modes, the mechanical performance for PBSL specimens under compression parallel to grain and perpendicular to grain are different as a whole. From the point of the characteristic values, the compression strength parallel to grain is 2.1 times of the compression strength perpendicular to grain. The elastic modulus for compression parallel to grain is 3.64 times of the compression strength perpendicular to grain. While the compression ratios along two compression directions are equal to each other. The bigger Poisson ratios for one typical side surface is 3.93 times of that for another typical side surface for PBSL specimens under compression perpendicular to grain, and the bigger value is equal to that for PBSL specimens under compression parallel to grain. Length can influence the mechanical properties of the PBSL specimens. The size 50 mm × 50 mm × 100 mm should be good choice for the standard or code to measure the compression strength. PBSL materials have better ductility under compression parallel to grain than that under compression perpendicular to grain. Stress-strain relationship models were proposed for PBSL specimens under compression parallel to grain and perpendicular to grain, respectively. These proposed models gave a good agreement with the test results.
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