The temperature dependence of the magnetic susceptibility, the magnetization at 4.2 K in fields up to 35 T, and the specific heat between 1.3 and 40 K in fields up to 5 T of the ternary Ce intermetallic compounds CeCuX (X = Si, Ge, Sn) have been studied. All three compounds form in ordered ternary structures related to the hexagonal AlB, type. Ferromagnetic order is found below 14.9 K for CeCuSi and below 10.2 K for CeCuGe. The magnetic order of CeCuSn below 8.6 K is of antiferromagnetic type but probably complex. as indicated by a double peak in the specific heat and the occurrence of a very low zero-field moment.
IDH2 encodes a mitochondrial metabolic enzyme that converts isocitrate to α-ketoglutarate (α-KG) by reducing nicotinamide adenine dinucleotide phosphate (NADP+) to NADPH and participates in the citric acid cycle for energy production. Notably, this gene has been shown to be critical for cell proliferation. The abnormal expression of IDH2 has been reported in several types of cancer, and mutations in IDH2 have been identified in gliomas and acute myelogenous leukemia. The overexpression of IDH2 has been reported in endometrial, prostate and testicular cancer as well as in Kashin-Beck disease. In this study, we observed that IDH2 expression was significantly downregulated in early phase but was upregulated in advanced phase colon carcinoma compared to peritumoral tissues. In addition, we demonstrated that the growth of a colon carcinoma cell line was inhibited by IDH2-siRNA and increased following transfection with an IDH2-overexpressing plasmid. These results indicate that IDH2 may play a unique role in the development of colon carcinoma.
The shortage of land resources on the Loess Plateau has long been a thorny problem. Many high-fill projects are carried out, accompanied by a series of geological hazards, which threaten the ecological environment and personal safety. The creep characteristics of loess are an essential part of loess landslide research. The microstructural changes are closely related to creep behavior. By conducting triaxial creep experiments on Malan loess from the Yan’an area in China, scanning electron microscope (SEM) experiments on loess in different creep stages were carried out. Using qualitative and quantitative analyses of the microstructural characteristics of intact loess and remodeled loess during creep, the microstructural parameters were compared, and finally, the microscopic mechanisms during creep were analyzed. The qualitative analysis of remodeled loess during creep returned significantly higher results than it did for intact loess. During the creep process, among the microstructural parameters of loess change, the change in pore and particle size and shape were the most obvious, while the complexity of other microstructural parameters and orientation changed little. During the creep process of loess, the soil skeleton changed continuously, but the loess microstructure featured different changes at different levels of deviator stress.
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