This study aimed to investigate the association between PFASs exposure and the risk of NAFLD in the elderly. Our sample included 1420 participants (≥ 60 years) from the 2003-2014 NHANES study with available serum PFASs, covariates and outcomes. NAFLD was de ned based on the hepatic steatosis index. Weighted binary logistic regression was utilized to calculate the odds ratio (OR) and 95% con dence intervals for each chemical. Results suggested that each one unit increase in ln-transformed concentration of PFOA was positively associated with risk of NAFLD in adjusted models. PFNA was also signi cantly associated with NAFLD incidence in adjusted linear regression. The effect of PFOA or PFNA on NAFLD development was found to be linear in the trend test. This study added novel evidence that exposure to PFASs (PFOA and PFNA) might be associated with NAFLD development.

No abstract

Objectives: We aimed to investigate the effect of physical activity (PA) on non-alcoholic fatty liver disease (NAFLD) prevalence and long-term survival, particularly in some specific population such as those with different socioeconomic status (SES).Methods: Multivariate regression and interaction analyses were conducted to deal with confounders and interacting factors.Results: Active PA was associated with lower prevalence of NAFLD in both cohorts. Individuals with active-PA had better long-term survival compared to those with inactive-PA in both cohorts, and the results were only statistically significant in NAFLD defined by US fatty liver index (USFLI). We found clear evidence that the beneficial role of PA was more obvious in individuals with better SES, and the statistical significances were presented in both two hepatic steatosis index (HSI)-NAFLD cohorts from the NHANES III and NHANES 1999–2014. Results were consistent in all sensitivity analyses.Conclusion: We demonstrated the importance of PA in decrease the prevalence and mortality of NAFLD, and highlights the need for improving SES simultaneously to increase the protective effect of PA.

This study aimed to investigate the association between PFASs exposure and the risk of NAFLD in the elderly. Our sample included 1420 participants (≥ 60 years) from the 2003–2014 NHANES study with available serum PFASs, covariates and outcomes. NAFLD was defined based on the hepatic steatosis index. Weighted binary logistic regression was utilized to calculate the odds ratio (OR) and 95% confidence intervals for each chemical. Results suggested that each one unit increase in ln-transformed concentration of PFOA was positively associated with risk of NAFLD in adjusted models. PFNA was also significantly associated with NAFLD incidence in adjusted linear regression. The effect of PFOA or PFNA on NAFLD development was found to be linear in the trend test. This study added novel evidence that exposure to PFASs (PFOA and PFNA) might be associated with NAFLD development.