Photocrosslinked methacrylated natural macromolecular hydrogels for tissue engineering: A review

Yang, Xiaoli; Li, Xiaojing; Wu, Zhaoping; Cao, Lingling

doi:10.1016/j.ijbiomac.2023.125570

Cited by 17 publications

(9 citation statements)

References 135 publications

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“…Photocrosslinking is another chemical crosslinking method, which usually occurs under UV light, and offers unique advantages in 3D printing and tissue engineering [ 46 , 52 , 53 ]. Methacrylic anhydride-modified polymers are the most commonly polymerized materials for photocrosslinked hydrogels [ 45 ]. Gelatin methacryloyl (GelMA) is one of the most researched and is widely used in biomedical applications.…”

Section: Hydrogel Crosslinking Methods and Classificationmentioning

confidence: 99%

Hydrogel-based treatments for spinal cord injuries

Jia,

Zeng,

et al. 2023

Heliyon

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Section: Hydrogel Crosslinking Methods and Classificationmentioning

confidence: 99%

Hydrogel-based treatments for spinal cord injuries

Jia,

Zeng,

et al. 2023

Heliyon

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“…Current research focuses on in situ bioprinting applications for direct cartilage repair [ 101 , 102 ] or bioprinting human mesenchymal cells that will transdifferentiate into chondrogenic tissue [ 103 ]. In situ bioprinting may also be used for skin wound regeneration, providing accurate coverage of the affected area [ 104 ]. Scientists have developed a 3D bioprinter called the ‘SkinPen’ for skin regeneration, which uses a complex hydrogel controlled by ultrasound and ultraviolet light to enhance adhesive and morphological properties [ 105 ].…”

Section: 3d Cell Culturesmentioning

confidence: 99%

Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering

Górnicki,

Lambrinow,

Golkar-Narenji

et al. 2024

Nanomaterials

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Biomimetic scaffolds imitate native tissue and can take a multidimensional form. They are biocompatible and can influence cellular metabolism, making them attractive bioengineering platforms. The use of biomimetic scaffolds adds complexity to traditional cell cultivation methods. The most commonly used technique involves cultivating cells on a flat surface in a two-dimensional format due to its simplicity. A three-dimensional (3D) format can provide a microenvironment for surrounding cells. There are two main techniques for obtaining 3D structures based on the presence of scaffolding. Scaffold-free techniques consist of spheroid technologies. Meanwhile, scaffold techniques contain organoids and all constructs that use various types of scaffolds, ranging from decellularized extracellular matrix (dECM) through hydrogels that are one of the most extensively studied forms of potential scaffolds for 3D culture up to 4D bioprinted biomaterials. 3D bioprinting is one of the most important techniques used to create biomimetic scaffolds. The versatility of this technique allows the use of many different types of inks, mainly hydrogels, as well as cells and inorganic substances. Increasing amounts of data provide evidence of vast potential of biomimetic scaffolds usage in tissue engineering and personalized medicine, with the main area of potential application being the regeneration of skin and musculoskeletal systems. Recent papers also indicate increasing amounts of in vivo tests of products based on biomimetic scaffolds, which further strengthen the importance of this branch of tissue engineering and emphasize the need for extensive research to provide safe for humansbiomimetic tissues and organs. In this review article, we provide a review of the recent advancements in the field of biomimetic scaffolds preceded by an overview of cell culture technologies that led to the development of biomimetic scaffold techniques as the most complex type of cell culture.

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“…Furthermore, this modification also enables precise adjustments to its mechanical properties, providing greater flexibility and tunability in its application. In comparison, synthetic materials utilized in hydrogel formation offer other advantages such as stability, customizability, ease of modification, and enhanced mechanical properties [111,112]. However, there are also drawbacks to consider-in particular, potential issues with biological inertness, the slow biodegradation rate, and the generation of toxic degradation products [46].…”

Section: Pros and Consmentioning

confidence: 99%

Advances in Hydrogels for Meniscus Tissue Engineering: A Focus on Biomaterials, Crosslinking, Therapeutic Additives

Zhou,

Wang,

Jiang

et al. 2024

Gels

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Meniscus tissue engineering has emerged as a promising strategy for meniscus repair and regeneration. As versatile platforms, hydrogels have gained significant attention in this field, as they possess tunable properties that allow them to mimic native extracellular matrices and provide a suitable microenvironment. Additionally, hydrogels can be minimally invasively injected and can be adjusted to match the shape of the implant site. They can conveniently and effectively deliver bioactive additives and demonstrate good compatibility with other functional materials. These inherent qualities have made hydrogel a promising candidate for therapeutic approaches in meniscus repair and regeneration. This article provides a comprehensive review of the advancements made in the research on hydrogel application for meniscus tissue engineering. Firstly, the biomaterials and crosslinking strategies used in the formation of hydrogels are summarized and analyzed. Subsequently, the role of therapeutic additives, including cells, growth factors, and other active products, in facilitating meniscus repair and regeneration is thoroughly discussed. Furthermore, we summarize the key issues for designing hydrogels used in MTE. Finally, we conclude with the current challenges encountered by hydrogel applications and suggest potential solutions for addressing these challenges in the field of MTE. We hope this review provides a resource for researchers and practitioners interested in this field, thereby facilitating the exploration of new design possibilities.

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Photocrosslinked methacrylated natural macromolecular hydrogels for tissue engineering: A review

Cited by 17 publications

References 135 publications

Hydrogel-based treatments for spinal cord injuries

Hydrogel-based treatments for spinal cord injuries

Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering

Advances in Hydrogels for Meniscus Tissue Engineering: A Focus on Biomaterials, Crosslinking, Therapeutic Additives

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