Association Between Physical Activity and Prevalence/Mortality of Non-Alcoholic Fatty Liver Disease in Different Socioeconomic Settings

Chen, Weili; Cao, Lingling; Wu, Zhaoping

doi:10.3389/ijph.2023.1605031

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…Work status was a dichotomous variable and was defined by the type of work performed in the last week; the responses of “employed at a job or business” and “with a job or business but not at work” were considered employed (coded as 0), and “looking for work” and “unemployed” were considered unemployed (coded as 1) [ 44 ].…”

Section: Methodsmentioning

confidence: 99%

Associations of Lifestyle Patterns With Overweight and Depressive Symptoms Among United States Emerging Adults With Different Employment Statuses

Xie,

Fan,

Luo

et al. 2023

Int J Public Health

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Objective: To identify lifestyle patterns in emerging adults and examine the association of lifestyle patterns with overweight and depression.Methods: Data was from the National Health and Nutrition Examination Survey between 2011 and 2018. A latent class analysis (LCA) was conducted with 2,268 US emerging adults based on sedentary behavior, moderate-to-vigorous physical activity, diet, sleep, alcohol drinking, and cigarette smoking. The associations of lifestyle groups with overweight and depression were examined by logistic regression and were further stratified by employment status.Results: The LCA results favored a four-class solution: “unhealthy but non-substance use” (59%), “healthy but sleepless and drinking” (12%), “unhealthy lifestyle” (15%), and “healthy but sedentary” group (14%). Compared to the “unhealthy lifestyle” group, participants in the “unhealthy but non-substance use” (coef. = −1.44, SE = 0.27; OR = 0.40, 95% CI [0.26, 0.61]), “healthy but sleepless and drinking” (coef. = −1.49, SE = 0.35; OR = 0.38, 95% CI [0.20, 0.72]), and “healthy but sedentary” (coef. = −1.97, SE = 0.34; OR = 0.29, 95% CI [0.14, 0.57]) groups had lower depression severity and reported fewer depressive symptoms. Moreover, lifestyle groups and health outcomes showed different relationships among employed and unemployed participants.Conclusion: This study found that the combinations of lifestyle behaviors had synergistic effects on mental health, and such effects differed by employment status.

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Section: Methodsmentioning

confidence: 99%

Associations of Lifestyle Patterns With Overweight and Depressive Symptoms Among United States Emerging Adults With Different Employment Statuses

Xie,

Fan,

Luo

et al. 2023

Int J Public Health

View full text Add to dashboard Cite

show abstract

“…Even modest amount of physical activity, compared to inactivity, is associated with reduced risk of NAFLD [ 10 ] and sedentary behavior is associated with higher risk of metabolic comorbidities including NAFLD [ 11 – 13 ]. Furthermore, previous studies connected lower socioeconomic status to higher rates of NAFLD and its severity [ 14 ] and found significant interactions between physical activity and socioeconomic status on NAFLD prevalence in a large NHANES III and NHANES 1999–2014 cohorts [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Socioeconomic status and health disparities drive differences in accelerometer-derived physical activity in fatty liver disease and significant fibrosis

Tabacu,

Swami,

Ledbetter

et al. 2024

PLoS ONE

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Background and aims The cornerstone of clinical management of patients with nonalcoholic fatty liver disease (NAFLD) are lifestyle changes such as increasing physical activity (PA) aimed at improving cardiometabolic risk. To inform NAFLD prevention and treatment guidelines we aimed to: (i) quantify the role of PA on lowering the risk for NAFLD and fibrosis; (ii) characterize NAFLD and fibrosis association with PA in the context of socioeconomic environment. Methods A sample of 2648 participants from the NHANES 2003–2006 was selected to develop survey weighted multivariable logistic regression models for predicting NAFLD and significant fibrosis, diagnosed non-invasively via fatty liver index (FLI) and fibrosis-4 (FIB-4) index. The PA measures were obtained from a hip-worn accelerometer. Results The predictive model for NAFLD showed AUC of 0.687 and a decrease of 43% in NAFLD risk with moderate vigorous PA (MVPA) (OR = 0.569, p < 0.001). The predictive model for fibrosis had AUC of 0.755 and there was a 48% and a 70% decrease in significant fibrosis risk with MVPA (OR = 0.518, p = 0.022) and total log activity count (TLAC) (OR = 0.296, p = 0.017), respectively. Participants with NAFLD and NAFLD with fibrosis engage in declining PA. Despite having jobs with higher level of PA and participating in more moderate-to-vigorous PA, a larger proportion of Hispanics participants had NAFLD and significant fibrosis. Conclusions These findings demonstrate the role of PA as a protective factor against the presence of NAFLD and significant fibrosis. Protective levels of PA in NAFLD differ by races.

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Social Determinants of Health Factors Associated with Metabolic Dysfunction-Associated Steatotic Liver Disease Prevalence and Severity: A Systematic Review and Meta-analysis

Abu-Rumaileh,

Dhoop,

Pace

et al. 2024

Preprint

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Background & Aims: Social determinants of health (SDOH) impact disease risk and severity leading to health disparities and impeding health equity. Though important in mitigating adverse health outcomes, SDOH impacting metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence and severity are understudied and results are conflicting. The aim of this systematic review and meta-analysis was to assess the impact of specific SDOH factors on MASLD disease burden for adults in the United States (US). Methods: We searched MEDLINE, Embase and Cochrane databases per the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Studies from January 2010- May 2024 were included. Quantitative studies of adults in the US that evaluated SDOH beyond race/ethnicity were included. Outcomes included prevalence of MASLD, metabolic dysfunction-associated steatohepatitis (MASH), MASH-associated advanced fibrosis or cirrhosis and clinical outcomes. Results: We identified 18 studies comprising of 547,634 total subjects from 11 unique cohorts. Nine studies evaluated MASLD prevalence, three MASH prevalence, eight MASH-associated advanced fibrosis/cirrhosis prevalence, and nine clinical outcomes. High diet quality was the most consistent SDOH factor associated with both MASLD and MASH-associated advanced fibrosis/cirrhosis prevalence (summarized OR of 0.76 p <0.01, and 0.74 p <0.01, respectively). Lower income was most consistently associated with risk of clinical outcomes (significant in 3/9 studies). Conclusions: Diet quality was the most consistent SDOH associated with disease prevalence and severity in MASLD, with the remainder of SDOH showing inconsistent associations. Prospective assessments using consistent, validated tools to assess the impact of specific SDOH on MASLD disease burden are needed to inform public health interventions to mitigate health disparities in MASLD.

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Association Between Physical Activity and Prevalence/Mortality of Non-Alcoholic Fatty Liver Disease in Different Socioeconomic Settings

Cited by 4 publications

References 35 publications

Associations of Lifestyle Patterns With Overweight and Depressive Symptoms Among United States Emerging Adults With Different Employment Statuses

Associations of Lifestyle Patterns With Overweight and Depressive Symptoms Among United States Emerging Adults With Different Employment Statuses

Socioeconomic status and health disparities drive differences in accelerometer-derived physical activity in fatty liver disease and significant fibrosis

Social Determinants of Health Factors Associated with Metabolic Dysfunction-Associated Steatotic Liver Disease Prevalence and Severity: A Systematic Review and Meta-analysis

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