Evidence of elastic to plastic transition in the zona pellucida of oocytes using atomic force spectroscopy Appl. Phys. Lett. 94, 153902 (2009); Atomic force microscopy ͑AFM͒ was used to comparatively study the structure of the bone matrix of rat tibia from an intact region with that from regions submitted to surgical injury. We used young male adult rats ͑Wistar͒, with corporal masses between 250 and 300 g. Each injury was provoked by drilling a 1.5-mm-diam hole in one cortical tibia surface. The healing course was monitored at 8 and 15 days after the injury. Atomic force microscopy images, at different magnifications, allowed the identification of the time dependence of the osteoblast activity, measured by the increase in the area of neoformed primary bone and in the organization of the collagen fibers of the bone matrix. Characterization of the natural recovery of the damaged bone tissue by AFM is potentially of great importance because it allows the comparison of natural recovery processes with those induced by medicines and other therapeutic procedures.
Single ricin detection by atomic force microscopy chemomechanical mapping Appl. Phys. Lett. 95, 043103 (2009); 10.1063/1.3190197 Atomic force microscopy of protein films and crystals Rev. Sci. Instrum. 78, 093704 (2007); 10.1063/1.2785032Effect of hydrogen etching on 6H SiC surface morphology studied by reflection high-energy positron diffraction and atomic force microscopy An atomic force microscopy study of the surface morphology of InP/GaAs heteroepitaxial layers subjected to rapid thermal annealing
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