Oral cancer is a common malignant tumor in the maxillofacial regions. Surgical resection is the preferred treatment, but severe functional impairment after surgery forces us to look for noninvasive treatments....
In
orthopedics, developing functionalized biomaterials to enhance
osteogenesis and bacterial resistance is crucial. Although poly(ether
ether ketone) (PEEK) is regarded as an important engineering plastic
for biomedical material with excellent mechanical properties and biocompatibility,
its biological inertness has greatly compromised its application in
biomedical engineering. Inspired by the catecholamine chemistry of
mussels, we propose a universal and versatile approach for enhancing
the osteogenesis and antibacterial performances of PEEK based on surface
functionalization of polydopamine-modified nanohydroxyapatite and
lysozyme simultaneously. The characterizations of surface morphology
and elemental composition revealed that the composite coating was
successfully added to the PEEK surface. Additionally, the in vitro cell experiment and biomineralization assay indicated
that the composite coating-modified PEEK was biocompatible with significantly
improved bioactivity to promote osteogenesis and biomineralization
compared with the untreated PEEK. Furthermore, the antibacterial test
demonstrated that the composite coating had a strongly destructive
effect on two bacteria (Staphylococcus aureus and Escherichia coli) with antibacterial ratios of 98.7% and
96.1%, respectively. In summary, the bioinspired method for surface
functionalization can enhance the osteogenesis and bacterial resistance
of biomedical materials, which may represent a potential approach
for designing functionalized implants in orthopedics.
Skin and soft tissue infection (SSTI) is an inflammatory condition caused by bacteria, and the eradication of biofilms is an important problem when treating such infections. Because of the low dispersibility and biofilm permeability of magnetic antibacterial materials, biofilm removal is difficult and infection persists. To solve these problems, inspired by conventional cloud bombs, a magnetic “nano‐cloud bomb” by adjusting the synthesis ratio to alter the shape of an assembled zeolitic imidazolate framework (ZIF), namely ZIF‐L‐Fe, is synthesized simply and rapidly. ZIF‐L‐Fe has a flower‐like clustered structure with sharp edges, which prevents the stacking of 2D ZIF nanoleaves, thereby enhancing the dispersion of Fe nanoparticles and increasing biofilm penetration under the action of magnetism. Additionally, ZIF‐L‐Fe retains the photothermal and catalytic properties of nanoparticles, which can kill methicillin‐resistant Staphylococcus aureus (MRSA) at low temperature and efficiently catalyze hydrogen peroxide (H2O2). Because of its magnetic effect, ZIF‐L‐Fe can rapidly penetrate biofilm, thus forming craters and destroying the local biofilm structure. Accordingly, the proposed strategy of clustered ZIF‐loaded delivery of Fe provides a novel concept that requires further development for clinical application to the treatment of biofilm infections.
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