Tumor-targeted biomimetic nanoplatform precisely integrates photodynamic therapy and autophagy inhibition for collaborative treatment of oral cancer

Dai, Hao; Yan, Han; Ding, Fan; Zhang, Ludan; Du, Ning; Sun, Lisha; Li, Ningyu; Yu, Guohui; Yang, Zeyuan; Wang, Yuguang; Huang, Mianliang

doi:10.1039/d1bm01780b

Cited by 19 publications

(17 citation statements)

References 36 publications

(33 reference statements)

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“…Due to its shallow location and high clinical operability, oral cancer shows high application potential regarding PTT and PDT [ 110 ]. A CQ-loaded nanoformulation based on cancer cell membranes was designed for the treatment of oral squamous cell carcinoma by the Dai group [ 80 ]. After high accumulation in tumor tissue, the nanoformulation can be activated under 660 nm laser irradiation and generate ROS, which synergizes with the subsequent release of CQ for anticancer effects.…”

Section: Reviewmentioning

confidence: 99%

“…In the early stages of intervention with nanoagents and laser irradiation, both bare NPs and cancer cell membrane-encapsulated NPs exhibited good tumor suppressive effects. However, the tumors in mice treated with bare NPs began to gradually increase in size after day 12 of treatment, whereas the biomimetic NPs still exhibited efficient antitumor effects [ 80 ]. In contrast to the poor tissue penetration of PDT, ultrasound-based sonodynamic therapy (SDT) shows stronger tissue penetration [ 111 ].…”

Section: Reviewmentioning

confidence: 99%

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Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

Lin¹,

Peng²,

Yu³

et al. 2023

Beilstein J. Nanotechnol.

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Immune clearance and insufficient targeting have limited the efficacy of existing therapeutic strategies for cancer. Toxic side effects and individual differences in response to treatment have further limited the benefits of clinical treatment for patients. Biomimetic cancer cell membrane-based nanotechnology has provided a new approach for biomedicine to overcome these obstacles. Biomimetic nanoparticles exhibit various effects (e.g., homotypic targeting, prolonging drug circulation, regulating the immune system, and penetrating biological barriers) after encapsulation by cancer cell membranes. The sensitivity and specificity of diagnostic methods will also be improved by utilizing the properties of cancer cell membranes. In this review, different properties and functions of cancer cell membranes are presented. Utilizing these advantages, nanoparticles can exhibit unique therapeutic capabilities in various types of diseases, such as solid tumors, hematological malignancies, immune system diseases, and cardiovascular diseases. Furthermore, cancer cell membrane-encapsulated nanoparticles show improved effectiveness and efficiency in combination with current diagnostic and therapeutic methods, which will contribute to the development of individualized treatments. This strategy has promising clinical translation prospects, and the associated challenges are discussed.

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Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

Lin¹,

Peng²,

Yu³

et al. 2023

Beilstein J. Nanotechnol.

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show abstract

“…9 Additionally, neoantigens based on the tumour cell membrane exhibit significant homologous targeting ability in the process of tumour therapy. 17 Cancer with genetic diversity not only presents differences between individuals but also intensifies as the disease advances. 18 Consequently, the effectiveness of standard treatment approaches varies significantly from one patient to another, underscoring the pressing need for precision therapy.…”

Section: Introductionmentioning

confidence: 99%

Advancing nanotechnology for neoantigen-based cancer theranostics

Zou,

Zhang,

Pan

et al. 2024

Chem. Soc. Rev.

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“…Photodynamic therapy (PDT) is a promising new treatment for various diseases due to its high level of "time-space" controllability and minimal adverse tissue effects. [14][15][16][17][18][19] It destroys lipids, proteins, and nucleic acids, making it beneficial for inactivating viruses in biological fluids and treating viral lesions on the skin and mucous membranes. [20][21][22] Photodynamic therapy can be divided into type I and type II therapies.…”

Section: Introductionmentioning

confidence: 99%

Molecular Engineering of AIE Photosensitizers for Inactivation of Rabies Virus

Bai

Liu

et al. 2023

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Rabies is a zoonotic neurological disease caused by the rabies virus (RABV) that is fatal to humans and animals. While several post‐infection treatment have been suggested, developing more efficient and innovative antiviral methods are necessary due to the limitations of current therapeutic approaches. To address this challenge, a strategy combining photodynamic therapy and immunotherapy, using a photosensitizer (TPA‐Py‐PhMe) with high type I and type II reactive oxygen species (ROS) generation ability is proposed. This approach can inactivate the RABV by killing the virus directly and activating the immune response. At the cellular level, TPA‐Py‐PhMe can reduce the virus titer under preinfection prophylaxis and postinfection treatment, with its antiviral effect mainly dependent on ROS and pro‐inflammatory factors. Intriguingly, when mice are injected with TPA‐Py‐PhMe and exposed to white light irradiation at three days post‐infection, the onset of disease is delayed, and survival rates improved to some extent. Overall, this study shows that photodynamic therapy and immunotherapy open new avenues for future antiviral research.

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Tumor-targeted biomimetic nanoplatform precisely integrates photodynamic therapy and autophagy inhibition for collaborative treatment of oral cancer

Abstract: Oral cancer is a common malignant tumor in the maxillofacial regions. Surgical resection is the preferred treatment, but severe functional impairment after surgery forces us to look for noninvasive treatments....

Cited by 19 publications

References 36 publications

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

Advancing nanotechnology for neoantigen-based cancer theranostics

Molecular Engineering of AIE Photosensitizers for Inactivation of Rabies Virus

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