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BACKGROUND Many studies have investigated the relationships between vitamins and esophageal cancer (EC). Most of these studies focused on the roles of vitamins in the prevention and treatment of EC, and few studies have examined the changes in vitamin nutritional status and their influencing factors before and after chemotherapy for EC. Chemotherapy may have a considerable effect on EC patients’ vitamin levels and hematological indicators. AIM To research the nutritional status of multiple vitamins in EC patients during chemotherapy and to assess its clinical significance. METHODS EC patients admitted to our center from July 2017 to September 2020 were enrolled in this study. Serum concentrations of nine vitamins (A, D, E, B 9 , B 12 , B 1 , C, B 2 and B 6 ), hemoglobin, total protein, albumin, blood calcium, blood phosphorus concentrations and body mass index (BMI) were measured in all EC patients. The changes in nine vitamins, hematological indicators and BMI were compared before and after two cycles of chemotherapy. The possible influential factors were analyzed. RESULTS In total, 203 EC patients receiving chemotherapy were enrolled in this study. Varying degrees of vitamin A, D, C and B 2 deficiency and weight loss were found in these patients, and the proportions of vitamin B 2 and vitamin C deficiencies increased significantly after chemotherapy (both P < 0.05). Serum concentrations of vitamins A, C, B 2 and B 6 and BMI before and after chemotherapy were statistically significant (all P < 0.05). Multivariate analysis showed that vitamin A levels significantly differed between male and female EC patients, whereas vitamin D concentration significantly differed in EC patients in different stages (all P < 0.05). Correlations were observed between the changes in serum concentrations of vitamin A and C before and after two cycles chemotherapy and the change in BMI ( P < 0.05). Hemoglobin, total protein, serum albumin and blood calcium concentrations significantly decreased in EC patients after chemotherapy (all P < 0.05), while the blood phosphorus level significantly increased after chemotherapy ( P < 0.05). Using the difference in vitamin concentrations as the independent variables and the difference in BMI as the dependent variable, logistic regression analysis revealed statistically significant differences for vitamin A, vitamin D and vitamin C (F = 5.082, P = 0.002). CONCLUSION Vitamin A, D, C and B 2 were mainly deficient in p...

Key indicatorsSingle-crystal X-ray study T = 292 K Mean (C-C) = 0.003 Å R factor = 0.056 wR factor = 0.159 Data-to-parameter ratio = 16.7For details of how these key indicators were automatically derived from the article, see Figure 1 View of (I), showing the labelling scheme for the non-H atoms and 50% probability displacement ellipsoids.organic papers o3644 Cui et al. C 23 H 26 N 4 OS Acta Cryst. (2005). E61, o3642-o3644

Fused pyrimidine derivatives R 0515 A Facile Synthesis and Fungicidal Activities of Novel Fluorine-Containing Pyrido[4,3-d]pyrimidin-4(3H)-ones.-Aza-Wittig reaction of iminophosphorane (I) followed by annulation reaction of the formed carbodiimide (III) with phenols (IV) and amines (VI) affords title compounds (V) and (VII), resp., in good yields. Some of them possess marked fungicidal activities and could be further developed as lead compounds. -(REN, Q.; CUI, Z.; HE*, H.; GU, Y.; J.

Key indicatorsSingle-crystal X-ray study T = 292 K Mean (C-C) = 0.004 Å R factor = 0.058 wR factor = 0.149 Data-to-parameter ratio = 17.5For details of how these key indicators were automatically derived from the article, see