Changes in the nutritional status of nine vitamins in patients with esophageal cancer during chemotherapy

Abstract

BACKGROUND Many studies have investigated the relationships between vitamins and esophageal cancer (EC). Most of these studies focused on the roles of vitamins in the prevention and treatment of EC, and few studies have examined the changes in vitamin nutritional status and their influencing factors before and after chemotherapy for EC. Chemotherapy may have a considerable effect on EC patients’ vitamin levels and hematological indicators. AIM To research the nutritional status of multiple vitamins in EC patients during chemotherapy and to assess its clinical significance. METHODS EC patients admitted to our center from July 2017 to September 2020 were enrolled in this study. Serum concentrations of nine vitamins (A, D, E, B 9 , B 12 , B 1 , C, B 2 and B 6 ), hemoglobin, total protein, albumin, blood calcium, blood phosphorus concentrations and body mass index (BMI) were measured in all EC patients. The changes in nine vitamins, hematological indicators and BMI were compared before and after two cycles of chemotherapy. The possible influential factors were analyzed. RESULTS In total, 203 EC patients receiving chemotherapy were enrolled in this study. Varying degrees of vitamin A, D, C and B 2 deficiency and weight loss were found in these patients, and the proportions of vitamin B 2 and vitamin C deficiencies increased significantly after chemotherapy (both P < 0.05). Serum concentrations of vitamins A, C, B 2 and B 6 and BMI before and after chemotherapy were statistically significant (all P < 0.05). Multivariate analysis showed that vitamin A levels significantly differed between male and female EC patients, whereas vitamin D concentration significantly differed in EC patients in different stages (all P < 0.05). Correlations were observed between the changes in serum concentrations of vitamin A and C before and after two cycles chemotherapy and the change in BMI ( P < 0.05). Hemoglobin, total protein, serum albumin and blood calcium concentrations significantly decreased in EC patients after chemotherapy (all P < 0.05), while the blood phosphorus level significantly increased after chemotherapy ( P < 0.05). Using the difference in vitamin concentrations as the independent variables and the difference in BMI as the dependent variable, logistic regression analysis revealed statistically significant differences for vitamin A, vitamin D and vitamin C (F = 5.082, P = 0.002). CONCLUSION Vitamin A, D, C and B 2 were mainly deficient in p...

Trends in nutritional status and factors affecting prognostic nutritional index in ovarian cancer patients during chemotherapy: a prospective longitudinal study based on generalized estimating equations

“…This result aligns with previous studies [ 40 – 42 ]. Moreover, we observed a continuous reduction in hemoglobin levels over time during chemotherapy, contrasting with findings by Movahed et al [ 25 ] and Liang et al [ 26 ]. The multi-factorial and complex mechanisms of cancer anemia, including malnutrition, make it a recognized independent prognostic factor for poor patient survival [ 43 ].…”

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Evaluation of nutrition components within prehabilitation programs in gastrointestinal cancers: Is prehab worth the hype?

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“…Micronutrient deficiencies can be screened and assessed for part of a comprehensive assessment, including biochemical data, and an NFPE. Corrections of micronutrients before surgery should be a priority because untreated micronutrient deficiencies, such as iron, thiamin, vitamin B 12 , or vitamin D deficiency, can lead to undesired postoperative complications 59–61 . On the other hand, some patients supplement their diet with high‐dose vitamins, immunostabilizing micronutrients, and antioxidants without input from the treating physician.…”

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