A facile synthesis and fungicidal activities of novel fluorine-containing pyrido[4,3-d]pyrimidin-4(3H)-ones

Ren, Qingyun; Cui, Ze-Ping; He, Hongwu; Gu, Yu‐Cheng

doi:10.1016/j.jfluchem.2007.06.007

Cited by 20 publications

(18 citation statements)

References 21 publications

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“…On the other hand, pyrimidine derivatives constitute an important class of compounds possessing diverse type of pharmacological activities viz. antimalarial (Agarwal et al 2005;Stocks et al 2002); antifilerial (Katiyar et al 2005); fungicidal (Ren et al 2007); antibacterial (Ali et al 2003;Gangjee et al 1997); antitoxoplasma (Saudi et al 2008); and antileismanial (Sunduru et al 2006;Torrence et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and evaluation of in vitro antitubercular activity and antimicrobial activity of some novel 4H-chromeno[2,3-d]pyrimidine via 2-amino-4-phenyl-4H-chromene-3-carbonitriles

et al. 2010

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Novel 5-phenyl-1,5-dihydro-2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dithiones, 5-phenyl-3,5-dihydro-4H-chromeno[2,3-d]pyrimidin-4-ones, 7-phenyl-7,9-dihydro-8H pyrimido[5 0 ,4 0 :5,6]pyrano[3,2-h]quinolin-8-ones, and 4-amino-5-phenyl-1,5-dihydro-2H-chromeno[2,3-d]pyrimidine-2-thiones were synthesized form 2-amino-4-phenyl-4H-chromene-3-carbonitrile. The newly synthesized compounds were characterized by IR, 1 H-NMR, 13 C-NMR, Mass spectra, and Elemental analysis. The compounds were evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H 37 Rv and antibacterial activity against Staphylococcus Aureus [ATCC-25923] and Streptococcus pyogenes [MTCC-443] as Gram-positive, Escherichia coli [ATCC-25922], and Pseudomonas aeruginosa [MTCC-441] as Gram-negative bacterial strains and antifungal activity against Aspergillus niger [MTCC-282]. Some of these derivatives exhibited pronounced antitubercular and antimicrobial activities.

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Section: Introductionmentioning

confidence: 99%

Synthesis and evaluation of in vitro antitubercular activity and antimicrobial activity of some novel 4H-chromeno[2,3-d]pyrimidine via 2-amino-4-phenyl-4H-chromene-3-carbonitriles

et al. 2010

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“…The post-emergence herbicidal activity against each weed was evaluated. The fungicidal activity measurement method was adapted from [11]. The phosphonates were dissolved in DMF (0.5-1.0 mL) to the concentration of 1000 mg/L.…”

Section: Methodsmentioning

confidence: 99%

Synthesis and Biological Activity of 1‐(Substituted phenoxyacetoxy)‐1‐(pyridin‐2‐yl or thien‐2‐yl)methylphosphonates

Wang

Peng

et al. 2014

Journal of Heterocyclic Chem

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A series of novel O,O-dimethyl 1-(substituted phenoxyacetoxy)-1-(pyridin-2-yl or thien-2-yl)methylphosphonates 6a-n and 7a-d were synthesized. Their structures were confirmed by IR, 1 H NMR, mass spectroscopy, and elemental analyses. The results of preliminary bioassays show that some of the title compounds exhibit moderate to good herbicidal and fungicidal activities. For example, the title compounds 6a, 6c, 6l, 6m, and 7d possess 90-100% inhibition against most of the tested plants at the dosage of 1500 g ai/ha, whereas the title compounds 6b, 6g-h and 6n possess 92-100% inhibition against Fusarium oxysporum, Phyricularia grisea, Botrytis cinereapers, Gibberella zeae, Sclerotinia sclerotiorum, and Cercospora beticola at the concentration of 50 mg/L.

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“…The fungicidal activity of compounds 4 was screened against six fungi, Fusarium oxysporium, Rhizoctonia solani, Botrytis cinereapers, Gibberella zeae, Dothiorella gregaria and Colletotrichum gossypii according to the reported method [8] at a dosage of 50 mg/L.…”

Section: Biological Activitiesmentioning

confidence: 99%

Facile synthesis and biological activities of novel fluorine-containing pyrido[4,3-d]pyrimidines

Liao

Wang

et al. 2008

Journal of Fluorine Chemistry

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A facile synthesis and fungicidal activities of novel fluorine-containing pyrido[4,3-d]pyrimidin-4(3H)-ones

Cited by 20 publications

References 21 publications

Synthesis and evaluation of in vitro antitubercular activity and antimicrobial activity of some novel 4H-chromeno[2,3-d]pyrimidine via 2-amino-4-phenyl-4H-chromene-3-carbonitriles

Synthesis and evaluation of in vitro antitubercular activity and antimicrobial activity of some novel 4H-chromeno[2,3-d]pyrimidine via 2-amino-4-phenyl-4H-chromene-3-carbonitriles

Synthesis and Biological Activity of 1‐(Substituted phenoxyacetoxy)‐1‐(pyridin‐2‐yl or thien‐2‐yl)methylphosphonates

Facile synthesis and biological activities of novel fluorine-containing pyrido[4,3-d]pyrimidines

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