Biarum carduchrum extract leads to functional regeneration of the nigro-striatal pathway probably through the mechanisms associated with its antioxidant properties. The results showed that B. carduchrum might be effective in Parkinson's disease.
Parkinson is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. Pain and emotional disorders due to Parkinson negatively affect the quality of the patient's life. Biarum carduchrum is an antioxidant plant with some application in traditional medicine. The aim of this study is to evaluate the protective effects of Biarum carduchrum extract on pain and emotional disorders caused by 6-hydroxydopamine injection. Rats were randomly divided into 5 groups of 8 animals. The control group received normal saline. Parkinson's groups were subjected to the injection of 6-OHDA in the right anterior mid-brain (MFB). In third, fourth and fifth groups, rats received Biarum carduchrum extract at doses of 100, 200 and 400 mg/kg via gavage 7 days after induction of Parkinson for 14 days. On day 15 th , behavioral tests including forced swimming test and tail flick were performed. Treatment of Parkinsonian rats with Biarum carduchrum extract at doses of 100, 200 and 400 mg dramatically reduced the duration of immobility time in the forced swimming test. Rats treated by Biarum carduchrum extract at doses of 100, 200 and 400 mg showed significantly increased resistance to pain compared with Parkinsonian rats. The results of this study show that the Biarum carduchrum extract improves depression and pain induced by Parkinson, which is probably related to its antioxidant effects.
Background & Objective: Parkinson is a neurodegenerative disease that leads to incurable and debilitating conditions. Herbal extracts can afford protection against neurodegenerative diseases due to their bioactive compounds. In the present study, we investigated the effect of hydro-alcoholic extract of Biarum carduchrum on catalepsy and brain oxidative stress in rat's model of Parkinson's disease. Materials & Methods: Rats were randomly divided into five groups of eight animals. The control group was left intact. Parkinsonian group received an injection of 6hydroxydopamine (6-OHDA) in the right anterior mid-brain. Extract treated groups received hydro-alcoholic extract of B. carduchrum at doses of 100, 200 and 400 mg/kg by gavage seven days after 6-OHDA injection. 14 days after treatment, bar test was performed and lipid peroxide levels of different brain regions were determined. Data were analyzed by ANOVA followed by Tukey's test using SPSS22 software and P<0.05 was considered statistically significant. Results: In 6-OHDA-lesioned group bar time was increased significantly (P<0.05) when compared with the control group (122.50±90.12 versus 0.00±0.00). B. carduchrum at doses of 200 and 400 mg/kg significantly reduced 6-OHDA induced catalepsy (P<0.0.5). 6-OHDA treatment lead to significant increases in lipid peroxide levels of cerebellum, cortex, hippocampus and striatum (P<0.05). Administration of B. carduchrumextract at different doses caused significant reduction in the lipid peroxide levels of different brain regions (P<0.05). Conclusion: B. carduchrum extract ameliorated 6-OHDA-induced catalepsy and lipid peroxide level of brain in rat's model of Parkinson's disease.
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