: Nearly 15% of couples involve in infertility as a universal health issue. About 50% of infertility cases have been known to be associated with the male parameters. Oxidative stress (OS) represents an imbalance in the level of reactive ox-ygen species (ROS) and anti-oxidant. In fact, OS has been considered as one of the popular pathologies reported in about 50% of all infertile male. Therefore, the increased level of ROS may result in infertility via DNA damages or lipid peroxida-tion (LPO) as well as the enzymes inactivation and proteins oxidation in spermatozoa. Basically, OS results from the life-style variables. As the absence of antioxidant and the respective deficiencies in the semen cause OS, variations in the life-style and anti-oxidant regimes may be advantageous to treatment strategies for resolving such an issue. Actually, anti-oxidants like vitamins E and C, glutathione, coenzyme-Q10, carnitines, selenium, N-acetylcysteine, carotenoids, zinc, and pentoxifylline decline the OS-induced sperm damages.Therefore, the present review overviews the oxidative bio-chemistry associated with the sperm health and identifies which men would be most at risk of the oxidative infertility. Hence, the re-view would show the techniques provided to diagnose OS and diverse therapeutic options.

Background: Proper sexual function is an important factor that affects family strength. Recently, the issue of obesity and the influence of body mass index (BMI) on sexual function have received increasing research attention. Objectives: This study aimed to investigate the relationship between sexual function and its domains with obesity and central obesity. Methods: This cross-sectional study was conducted on 514 women aged 15 -45 years who presented at Shiraz healthcare centers in 2014 -2015. Simple random sampling was performed. Data were collected by applying the female sexual function index (FSFI), weight, and meter. The questionnaire consisted of 19 questions that evaluated six domains, as follows: sexual desire, arousal, lubrication, orgasm, satisfaction, and pain. Scores < 28 on the questionnaire were considered to represent sexual dysfunction. The results were analyzed using the t-test, Fisher test, Chi-square test, and Pearson correlation coefficient.

Breast cancer (BC) has been recognized as the most common type of cancer in females across the world, accounting for 12% of each cancer case. In this sense, better diagnosis and screening have been thus far proven to contribute to higher survival rates. Moreover, traditional (or standard) chemotherapy is still known as one of the several prominent therapeutic options available, though it suffers from unsuitable cell selectivity, severe consequences, as well as resistance. In this regard, nanobased drug delivery systems (DDSs) are likely to provide promising grounds for BC treatment. Liposomes are accordingly effective nanosystems, having the benefits of multiple formulations verified to treat different diseases. Such systems possess specific features, including smaller size, biodegradability, hydrophobic/hydrophilic characteristics, biocompatibility, lower toxicity, as well as immunogenicity, which can all lead to considerable efficacy in treating various types of cancer. As chemotherapy uses drugs to target tumors, generates higher drug concentrations in tumors, which can provide for their slow release, and enhances drug stability, it can be improved via liposomes in DDSs for BC treatment. Therefore, the present study aims to review the existing issues regarding BC treatment and discuss liposome‐based targeting in order to overcome barriers to conventional drug therapy.

Background: Sexual function is affected by various physiological and psychological factors. Individual differences and various personality types are effective in response to sexual function. Objective: The present study aimed to investigate the correlation between sexual function and personality types among the women referred to healthcare centers in Shiraz in 2014-2015. Methods: This cross-sectional, descriptive-analytical study was conducted on 514 women referred to healthcare centers in Shiraz. The study data were collected using a demographic information form, Female Sexual Function Index, and NEO Personality Inventory. Written informed consent forms were also obtained from the participants. After all, the data were analysed through the SPSS software, version 19, using t-test, chi-square test, and Fisher’s exact test. Results: The results showed that sexual desire disorder in 39% of the participants, sexual arousal disorder in 38.6%, orgasm disorder in 25.5%, and sexual pain in 33%. The results also indicated that sexual desire, arousal, and pain were significantly associated with extroversion and reversely related to neuroticism. Conclusions: The score of extroversion was higher in the individuals without sexual dysfunction, while the score of neuroticism was higher among those with sexual dysfunction. Therefore, it is necessary to evaluate the women’s personality types as a technique for assessment of sexual dysfunction.

Background:: Sexual dysfunction mainly results from psychological and personal causes. These causes, including self-esteem, have been considered to be the dominant reason for sexual dysfunction. Self-esteem is in fact among the basic factors in desirable personality development. Objective:: Investigation of the relationship between self-esteem and sexual dysfunction in women at reproductive ages referred to healthcare centers in Shiraz, Iran. Materials and Methods:: This epidemiological, analytical, cross-sectional study was conducted on 268 women at reproductive ages referred to healthcare centers in Shiraz in 2014-2015. The study data were collected using a demographic information form, Female Sexual Function Index, and Rosenberg Self-esteem Scale. Results:: The results revealed a significant relationship between self-esteem and sexual function (p=0.001), sexual desire (p=0.03), sexual arousal (p=0.01), and lubrication (p=0.026). However, no significant correlation was observed among self-esteem and orgasm (p=0.54), sexual satisfaction (p=0.3), and pain during intercourse (p=0.1). Investigation of the relationship between demographic indicators and self-esteem showed that the spouse's education level had a significant statistical relationship (p = 0.008) with self-esteem, while there was no significant relationship between self-esteem and women's education level, husband's job, income, Body Mass Index (BMI), and age of women. Conclusion:: The results indicated that self-esteem was associated with sexual dysfunction. Accordingly, individuals with lower self-esteem showed higher sexual dysfunction.

Abstract:: Male infertility is one of the major global health problems, in particular, in more than half of the affected men. Genetic factors are important for identifying men with idiopathic infertility along with semen analysis. Valid and useful information can be obtained through non-invasive molecular research. Among these, small single-stranded non-coding RNA molecules of microRNAs (abbreviated miRNAs) are non-invasive biomarkers with a diagnostic value by regulating the post-transcriptional gene silence through repression and prevention of the translation process. The association between various types of male infertility and miRNA regulation changes has been evaluated to understand the biological function of miRNA and gene targets. Accordingly, further study of the function of miRNAs associated with reproductive disorders could lead researchers to further understand the molecular mechanisms of male infertility in order to find effective biomarkers and therapeutic strategies. Therefore, the present review article aimed at scrutinizing those researches investigating the altered miRNA expression in testicles, epididymis, and spermatozoa.

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