Role of Oxidative Stress and Antioxidant Supplementation in Male Fertility

Beygi, Zahra

doi:10.2174/18755666mta5mntqt5

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To combat infectious pathogens, leukocytic infiltration is increased during infection. Increased inflammatory cytokine production, such as Interleukin-8 (IL-8), combined with reduced SOD synthesis results in a respiratory burst and increased ROS generation, leading to oxidative stress [3]. Sertoli cells have also been shown to be capable of producing ROS [4].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Reproduction Health: Physiology, Pathology, and Clinical Biomarkers

D’Amico,

Cuzzocrea,

Cordaro

et al. 2024

Reactive Oxygen Species - Advances and Developments

View full text Add to dashboard Cite

Reactive oxygen species (ROS) are free radicals derived from oxygen during normal cellular metabolism. Cells, under aerobic conditions, have a defense system against ROS, and in normal circumstances, there is an appropriate balance between prooxidants and antioxidants. When an overproduction of ROS develops or the body fails to eliminate ROS in excess, oxidative stress arises, during which ROS accumulate and damage cells and tissues. ROS plays a crucial role in the physiological processes and signaling pathways associated in both male and female fertility. In females, oxidative stress acts as a mediator in the modulation of important ovarian functions, and its complications such as abortions, recurrent pregnancy losses, preeclampsia, and gestational diabetes. In males, ROS plays an important role in normal physiological processes such as capacitation, hyperactivation, acrosome reaction, and sperm-oocyte fusion to ensure appropriate fertilization. However, high concentrations of ROS cause sperm pathologies (ATP depletion) in the form of inadequate axonemal phosphorylation or lipid peroxidation, resulting in a loss of sperm motility and viability. This chapter will highlight the mechanisms, production, physiological, and pathophysiological roles of ROS in relation to the male and female reproductive system, and recent advances in diagnostic methods that use ROS as biochemical markers.

show abstract

Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Reproduction Health: Physiology, Pathology, and Clinical Biomarkers

D’Amico,

Cuzzocrea,

Cordaro

et al. 2024

Reactive Oxygen Species - Advances and Developments

View full text Add to dashboard Cite

show abstract

“…Células espermáticas são especialmente susceptíveis ao desequilíbrio oxidativo devido ao seu volume citoplasmático reduzido (e consequentemente limitadas funções protetivas) e a presença de lipídios com alto grau de insaturação na sua membrana, que são a principal fonte de produção excessiva de EROs devido ao processo de peroxidação (AITKEN, 2003). O estresse oxidativo pode danificar o DNA do espermatozoide, bem como suas membranas e proteínas, comprometendo sua viabilidade e função (AITKEN, 2003;BEYGI Z. et al, 2021). Todos os estudos relacionados ao estresse oxidativo, bem como nos trabalhos de Aitken et al (1989de Aitken et al ( , 2001de Aitken et al ( , 2006de Aitken et al ( , 2014, sugerem que a membrana plasmática e sua composição lipídica sejam de extrema importância a qualidade espermática.…”

Section: Infertilidade Masculinaunclassified

Caracterização lipídica de espermatozoides de homens férteis e homens inférteis com oligoastenozoospermia

Caetano

View full text Add to dashboard Cite

À minha orientadora, Profª. Dra. Paula Andrea de Albuquerque Salles Navarro, pela dedicação ao projeto e confiança no meu trabalho mesmo nos momentos que deixei de acreditar.À minha irmã, Camila, por nunca medir esforços para estar por perto e sempre me apoiar nas minhas decisões com muito carinho.Ao meu companheiro de vida, Vinício, que esteve ao meu lado nos momentos bons e ruins, e me ajudou a passar por eles de forma branda e com amor.Ao meu filhotinho Bento, por toda paz e serenidade que me traz com sua doçura e amor incondicional.À Suelen e Fabi, que foram uma base de apoio muito importante nessa fase da minha vida e se tornaram grandes amigas que levarei para a vida toda.À Cris e Cidinha que além de me acompanharem em todos os meus desafios de laborátorio com paciência e sabedoria, me presentearam com suas palavras amigas deixando meus dias mais leves e divertidos.À Juliana Meola e Carol Mantovani, por estarem sempre dispostas a me ajudar em tudo que eu precisasse com carinho e amizade.Ao Murilo que se fez presente durante o desenvolvimento do projeto e não mediu esforços para me ajudar, e ao Eduardo que sempre me auxiliou prontamente. À Caroline, por sua amizade de longa data que só se fortalece com o passar dos anos.À secretaria de pós graduação pelo auxilio administrativo e a equipe de funcionários do

show abstract

Antioxidants for male infertility: therapeutic scheme and indications. A retrospective single-center real-life study

CANNARELLA,

CRAFA,

SAWAID KAIYAL

et al. 2024

Minerva Endocrinol

View full text Add to dashboard Cite

This single-center real-life study was conducted to evaluate the most effective combination of nutraceuticals and the most appropriate indications for the treatment of male infertile patients. Infertile patients aged 20-55 years were treated with a combination of antioxidants (Androlen®) (Group 1), with Androlen® and a mixture of brinolytic molecules (Lenidase®) (Group 2), or Androlen® and other molecules different from those used for the patients of the Group 2 (Group 3). Patients were also subdivided according to the presence of varicocele, mild testicular hypotrophy, idiopathic infertility, and chronic male accessory gland infection (MAGI).Forty-three patients were enrolled. In the overall analysis, only progressive motility signi cantly improved after therapy. Subgroup analysis showed a signi cant increase in progressive motility, total motile sperm count (TMSC), and in the percentage of alive spermatozoa after treatment in the Group A. Progressive motility improved signi cantly in patients with varicocele, while the TMSC in patients with varicocele and those with idiopathic. The percentage of alive spermatozoa increased in patients with testicular hypotrophy.Treatment with antioxidants increases progressive sperm motility. The association of brinolytic or other nutraceuticals does not improve the e cacy of the treatment with antioxidants alone. The treatment was effective in patients with varicocele or idiopathic infertility.

show abstract

Role of Oxidative Stress and Antioxidant Supplementation in Male Fertility

Cited by 3 publications

References 0 publications

Oxidative Stress and Reproduction Health: Physiology, Pathology, and Clinical Biomarkers

Oxidative Stress and Reproduction Health: Physiology, Pathology, and Clinical Biomarkers

Caracterização lipídica de espermatozoides de homens férteis e homens inférteis com oligoastenozoospermia

Antioxidants for male infertility: therapeutic scheme and indications. A retrospective single-center real-life study

Contact Info

Product

Resources

About