Massive pro-inflammatory cytokines production has been correlated with the pathogenesis of severe dengue disease. The active compound of mangosteen fruit pericarps, α-mangostin, has been commonly used as traditional medicine and dietary supplement. We examined the effect of α-mangostin against dengue virus (DENV) infection in human peripheral blood mononuclear cells (PBMC) by the measurement of virus titer and TNF-α and IFN-γ cytokines concentration post infection. Increasing concentration of α-mangostin inhibited virus replication and reduced inflammatory cytokines expression at 24- and 48-h post infection. Our results support the potential use of α-mangostin as anti-antiviral and anti-inflammatory therapies in the treatment of dengue.Graphic Abstract
Latar Belakang: Berdasarkan pengamatan awal masih ditemukan petugas selain rekam medis atau selain petugas filing yang masuk ke ruang filing. Pada pintu filing yang menuju ke bagian pendaftaran pintu tidak terkunci. Melindungi keamanan serta kerahasiaan ruang filing sangat diperlukan agar terhindar dari kejahatan, kecelakaan dan lainnya.Tujuan: mendeskripsikan keamanan dan kerahasiaan dokumen rekam medis diruang filing RS Roemani Muhammadiyah Semarang.Metode: Jenis penelitian yang digunakan adalah deskriptif dengan metode observasi dan wawancara.Hasil: Penelitian menunjukan dari segi aspek fisik sudah aman, sampul dokumen RM terbuat dari bahan kertas Art Karton 230gr. Ruangan filing tidak tersedia APAR, kamfer dan tracer. Petugas masih melakukan aktifitas makan dan minum di ruang filing. Pintu ke-2 tidak terkunci dan masih ada selain petugas rekam medis yang masuk ke ruang filing.Kesimpulan: Sebaiknya pihak rumah sakit melengkapi ruang filing dengan APAR, tracer, kamfer dan melakukan pemeliharaan kebersihan di ruang filing. Untuk menjaga kerahasiaan rekam medis pasien sebaiknya rumah sakit dengan tegas melarang selain petugas filing untuk masuk ke ruang filing.
Background: Minimum Service Standards have set up at Panti Wilasa Hospital Dr. Cipto Semarang that the standard time of outpatient services is 10 minutes which is calculated from the registration process. From the data obtained by the researcher from the assignment in carrying out the Minimal Standard of Service in serving the outpatients has been fully implemented. However, there are still healthcare service workers who do not understand the Minimum Service Standards when interviewing healthcare service officers in the Outpatient Registration Place section.Methods: This type of research is descriptive research that gives an overview of the data as a result of research. The method used is interviewing the outpatient registration officer and filing. Sampling technique in this study using random sampling data with a sample size of 30 person.Results: There is no specific Standard Operating Procedure (SOP) regarding the provision of outpatient medical records which were interviewed to the head of the medical records, which is already quite a good service at the outpatient registration place Dr. Panti Wilasa Hospital Cipto Semarang and Standard Operating Procedure (SOP) for Minimum Service Standards (SPM) in outpatient registration conducted interviews with the head of the medical record at Panti Wilasa Hospital Dr. Cipto Semarang. Results of the study showed that the average rapidity in medical record document provision was 31 minutes 20 seconds. At the Wilasa Panti Hospital Dr. Cipto Semarang, that the time for providing more medical records is more than ten minutes.Conclusions: The standard time for providing medical records is included in the Standard Operating Procedure (SOP) for the collection and compilation of medical records on a storage rack, so that medical records officers can work on the basis and rules that have been determined and the standard time for providing medical records is included in the quality objectives, The results are announced and written in a place easily seen by officers, Monitoring active medical record storage racks regularly by medical records officers and this can reduce the wrong medical record documents.
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