Ultrafine particles (UFP, particles <100 nm) are ubiquitous in ambient urban and indoor air from multiple sources and may contribute to adverse respiratory and cardiovascular effects of particulate matter (PM). Depending on their particle size, inhaled UFP are efficiently deposited in nasal, tracheobronchial, and alveolar regions due to diffusion. Our previous rat studies have shown that UFP can translocate to interstitial sites in the respiratory tract as well as to extrapulmonary organs such as liver within 4 to 24 h postexposure. There were also indications that the olfactory bulb of the brain was targeted. Our objective in this follow-up study, therefore, was to determine whether translocation of inhaled ultrafine solid particles to regions of the brain takes place, hypothesizing that UFP depositing on the olfactory mucosa of the nasal region will translocate along the olfactory nerve into the olfactory bulb. This should result in significant increases in that region on the days following the exposure as opposed to other areas of the central nervous system (CNS). We generated ultrafine elemental (13)C particles (CMD = 36 nm; GSD = 1.66) from [(13)C] graphite rods by electric spark discharge in an argon atmosphere at a concentration of 160 microg/m(3). Rats were exposed for 6 h, and lungs, cerebrum, cerebellum and olfactory bulbs were removed 1, 3, 5, and 7 days after exposure. (13)C concentrations were determined by isotope ratio mass spectroscopy and compared to background (13)C levels of sham-exposed controls (day 0). The background corrected pulmonary (13)C added as ultrafine (13)C particles on day 1 postexposure was 1.34 microg/lung. Lung (13)C concentration decreased from 1.39 microg/g (day 1) to 0.59 microg/g by 7 days postexposure. There was a significant and persistent increase in added (13)C in the olfactory bulb of 0.35 microg/g on day 1, which increased to 0.43 microg/g by day 7. Day 1 (13)C concentrations of cerebrum and cerebellum were also significantly increased but the increase was inconsistent, significant only on one additional day of the postexposure period, possibly reflecting translocation across the blood-brain barrier in certain brain regions. The increases in olfactory bulbs are consistent with earlier studies in nonhuman primates and rodents that demonstrated that intranasally instilled solid UFP translocate along axons of the olfactory nerve into the CNS. We conclude from our study that the CNS can be targeted by airborne solid ultrafine particles and that the most likely mechanism is from deposits on the olfactory mucosa of the nasopharyngeal region of the respiratory tract and subsequent translocation via the olfactory nerve. Depending on particle size, >50% of inhaled UFP can be depositing in the nasopharyngeal region during nasal breathing. Preliminary estimates from the present results show that approximately 20% of the UFP deposited on the olfactory mucosa of the rat can be translocated to the olfactory bulb. Such neuronal translocation constitutes an additional not generally r...
Renewable fresh water over continents has input from precipitation and losses to the atmosphere through evaporation and transpiration. Global-scale estimates of transpiration from climate models are poorly constrained owing to large uncertainties in stomatal conductance and the lack of catchment-scale measurements required for model calibration, resulting in a range of predictions spanning 20 to 65 per cent of total terrestrial evapotranspiration (14,000 to 41,000 km(3) per year) (refs 1, 2, 3, 4, 5). Here we use the distinct isotope effects of transpiration and evaporation to show that transpiration is by far the largest water flux from Earth's continents, representing 80 to 90 per cent of terrestrial evapotranspiration. On the basis of our analysis of a global data set of large lakes and rivers, we conclude that transpiration recycles 62,000 ± 8,000 km(3) of water per year to the atmosphere, using half of all solar energy absorbed by land surfaces in the process. We also calculate CO2 uptake by terrestrial vegetation by connecting transpiration losses to carbon assimilation using water-use efficiency ratios of plants, and show the global gross primary productivity to be 129 ± 32 gigatonnes of carbon per year, which agrees, within the uncertainty, with previous estimates. The dominance of transpiration water fluxes in continental evapotranspiration suggests that, from the point of view of water resource forecasting, climate model development should prioritize improvements in simulations of biological fluxes rather than physical (evaporation) fluxes.
Studies with intravenously injected ultrafine particles have shown that the liver is the major organ of their uptake from the blood circulation. Measuring translocation of inhaled ultrafine particles to extrapulmonary organs via the blood compartment is hampered by methodological difficulties (i.e., label may come off, partial solubilization) and analytical limitations (measurement of very small amounts). The objective of our pilot study was to determine whether ultrafine elemental carbon particles translocate to the liver and other extrapulmonary organs following inhalation as singlet particles by rats. We generated ultrafine (13)C particles as an aerosol with count median diameters (CMDs) of 20-29 nm (GSD 1.7) using electric spark discharge of (13)C graphite electrodes in argon. Nine Fischer 344 rats were exposed to these particles for 6 h. in whole-body inhalation chambers at concentrations of 180 and 80 microg/m(3); 3 animals each were killed at 0.5, 18, and 24 h postexposure. Six unexposed rats served as controls. Lung lobes, liver, heart, brain, olfactory bulb, and kidney were excised, homogenized, and freeze-dried for analysis of the added (13)C by isotope ratio mass spectrometry. Organic (13)C was not detected in the (13)C particles. The (13)C retained in the lung at 0.5 h postexposure was about 70% less than predicted by rat deposition models for ultrafine particles, and did not change significantly during the 24-h postexposure period. Normalized to exposure concentration, the added (13)C per gram of lung on average in the postexposure period was approximately 9 ng/g organ/microg/m(3). Significant amounts of (13)C had accumulated in the liver by 0.5 h postinhalation only at the high exposure concentration, whereas by 18 and 24 h postexposure the (13)C amount of the livers of all exposed rats was about fivefold greater than the (13)C burden retained in the lung. No significant increase in (13)C was detected in the other organs which were examined. These results demonstrate effective translocation of ultrafine elemental carbon particles to the liver by 1 d after inhalation exposure. Translocation pathways include direct input into the blood compartment from ultrafine carbon particles deposited throughout the respiratory tract. However, since predictive particle deposition models indicate that respiratory tract deposits alone may not fully account for the hepatic (13)C burden, input from ultrafine particles present in the GI tract needs to be considered as well. Such translocation to blood and extrapulmonary tissues may well be different between ultrafine carbon and other insoluble (metal) ultrafine particles.
We report data on the martian meteorite Northwest Africa (NWA) 7034, which shares some petrologic and geochemical characteristics with known martian meteorites of the SNC (i.e., shergottite, nakhlite, and chassignite) group, but also has some unique characteristics that would exclude it from that group. NWA 7034 is a geochemically enriched crustal rock compositionally similar to basalts and average martian crust measured by recent Rover and Orbiter missions. It formed 2.089 ± 0.081 billion years ago, during the early Amazonian epoch in Mars' geologic history. NWA 7034 has an order of magnitude more indigenous water than most SNC meteorites, with up to 6000 parts per million extraterrestrial H(2)O released during stepped heating. It also has bulk oxygen isotope values of Δ(17)O = 0.58 ± 0.05 per mil and a heat-released water oxygen isotope average value of Δ(17)O = 0.330 ± 0.011 per mil, suggesting the existence of multiple oxygen reservoirs on Mars.
In order to better calibrate pedogenic carbonate as a proxy for past environments, we compared the stable isotopic composition of soil CO 2 , soil water, and pedogenic carbonate in young soils from central New Mexico, USA. Seasonal changes in the δ 13 C value of soil CO 2 , the δ 18 O value of soil water, and the soil temperature were monitored to establish the timing of isotopic equilibrium with the carbonate. Calcite solubility was calculated from measured temperatures and CO 2 concentrations in the soil. This approach allowed us to determine the conditions associated with pedogenic carbonate formation. Carbon isotope equilibrium, oxygen isotope equilibrium, and minimum calcite solubility all occurred simultaneously during warm, dry conditions in May 2008 when soil CO 2 concentrations were low. It is therefore concluded that pedogenic carbonate forms during warm, dry periods and does not record mean growing season conditions as typically assumed. The seasonal bias in pedogenic carbonate formation may explain the occurrence of pedogenic carbonate in monsoon climates and its absence in regions where annual precipitation is more uniformly distributed. The implications of the seasonal bias for stable isotope-based paleoenvironmental reconstructions are that paleoelevations may have been previously over-or underestimated, paleoatmospheric CO 2 concentrations likely have been significantly overestimated, and pedogenic carbonate provides a C 4 -biased record of paleovegetation, especially in dry soils. Downloaded from REFERENCES CITEDAllison, G.B., 1982, The relationship between 18 O and deuterium in water in sand columns undergoing evapo-
Groundwater recharged by meteoric water supports human life by providing two billion people with drinking water and by supplying 40% of cropland irrigation. While annual groundwater recharge rates are reported in many studies, fewer studies have explicitly quantified intra-annual (i.e., seasonal) differences in groundwater recharge. Understanding seasonal differences in the fraction of precipitation that recharges aquifers is important for predicting annual recharge groundwater rates under changing seasonal precipitation and evapotranspiration regimes in a warming climate, for accurately interpreting isotopic proxies in paleoclimate records, and for understanding linkages between ecosystem productivity and groundwater recharge. Here we determine seasonal differences in the groundwater recharge ratio, defined here as the ratio of groundwater recharge to precipitation, at 54 globally distributed locations on the basis of 18 O/ 16 O and 2 H/ 1 H ratios in precipitation and groundwater. Our analysis shows that arid and temperate climates have wintertime groundwater recharge ratios that are consistently higher than summertime groundwater recharge ratios, while tropical groundwater recharge ratios are at a maximum during the wet season. The isotope-based recharge ratio seasonality is consistent with monthly outputs from a global hydrological model (PCR-GLOBWB) for most, but not all locations. The pronounced seasonality in groundwater recharge ratios shown in this study signifies that, from the point of view of predicting future groundwater recharge rates, a unit change in winter (temperate and arid regions) or wet season (tropics) precipitation will result in a greater change to the annual groundwater recharge rate than the same unit change to summer or dry season precipitation.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.