A dual stimuli-responsive n-octane-in-water Pickering emulsion with CO2/N2 and light triggers is prepared using negatively charged silica nanoparticles in combination with a trace amount of dual switchable surfactant, 4-butyl-4-(4-N,N-dimethylbutoxyamine) azobenzene bicarbonate (AZO-B4), as stabilizers. On one hand, the emulsion can be transformed between stable and unstable at ambient temperature rapidly via the N2/CO2 trigger, and on the other hand, a change in droplet size of the emulsion can occur upon light irradiation/rehomogenization cycles without changing the particle/surfactant concentration. The dual responsiveness thus allows for a precise control of emulsion properties. Compared with emulsions stabilized by specially synthesized stimuli-responsive particles or by stimuli-responsive surfactants, the method reported here is much easier and requires a relatively low concentration of surfactant (≈1/10 cmc), which is important for potential applications.
A telomerase-responsive DNA icosahedron was designed to precisely release caged platinum nanodrugs into cisplatin-resistance tumor cells for effective therapy. This DNA icosahedron was constructed from two pyramidal DNA cages connected with telomerase primers and telomeric repeats, and platinum nanodrugs were then encapsulated into the DNA structure. In the presence of telomerase, the primers are extended, leading to inner-chain substitution of the DNA icosahedron and subsequent release of the caged nanodrugs. This DNA icosahedron can precisely release caged nanodrugs in response to telomerase in tumor cells, giving enhanced anticancer efficacy in drug-resistant carcinoma and with reduced toxicity to normal tissues. We speculate that this precisely designed, well controlled DNA cage could be generalized to diverse anticancer drugs.
Atherosclerotic plaque is the primary cause of cardiovascular disorders and remains a therapeutic hurdle for the early intervention of atherosclerosis. Traditional clinical strategies are often limited by surgery‐related complications or unsatisfactory effects of long‐term drug administration. Inspired by the plaque‐binding ability of platelets, a biomimic photodynamic therapeutic system is designed to mitigate the progression of atherosclerotic plaques. This system is composed of photosensitizer‐loaded upconversion nanoparticle cores entrapped in the platelet membrane. The platelet membrane coating facilitates specific targeting of the therapeutic system to macrophage‐derived foam cells, the hallmark, and main component of early stage atherosclerotic plaques, which is firmly confirmed by in vivo fluorescent and single‐photon emission computed tomography/computed tomography (SPECT/CT) radionuclide imaging. Importantly, in vivo phototherapy guided by SPECT/CT imaging alleviates plaque progression. Further immunofluorescence analysis reveals foam cell apoptosis and ameliorated inflammation. This biomimic system, which combines plaque‐binding with radionuclide imaging guidance, is a novel, noninvasive, and potent strategy to mitigate the progression of atherosclerotic plaque.
AbstractSince graphene was first reported as a saturable absorber to achieve ultrafast pulses in fiber lasers, many other two-dimensional (2D) materials, such as topological insulators, transition metal dichalcogenides, black phosphorus, and MXenes, have been widely investigated in fiber lasers due to their broadband operation, ultrafast recovery time, and controllable modulation depth. Recently, solution-processing methods for the fabrication of 2D materials have attracted considerable interest due to their advantages of low cost, easy fabrication, and scalability. Here, we review the various solution-processed methods for the preparation of different 2D materials. Then, the applications and performance of solution-processing-based 2D materials in fiber lasers are discussed. Finally, a perspective of the solution-processed methods and 2D material-based saturable absorbers are presented.
We report a mode-locked fiber laser working at a 1 GHz fundamental repetition rate. The laser delivers a 600 mW average power at a pump power of 1800 mW. The pulse spectrum bandwidth was 23 nm to support 64 fs near-transform-limited pulses. An octave-spanning supercontinuum from 590 to 1350 nm was generated in a tapered photonic crystal fiber solely with the mode-locked fiber-laser output, without amplifiers. A 30 dB f(ceo) beat signal was detected via f-to-2f interferometer.
Lithium metal anodes are promising for application in new-type secondary batteries. Unfortunately, low cycle life and safety peril induced by uncontrollable dendrites growth and weak solid electrolyte interface (SEI) have blocked their utilization. In this work, an interlamellar lithium-ion conductor of lithium-montmorillonite (Li-MMT) is applied to enhance the SEI properties, inhibit dendritesgermination, and thus significantly enhance electrochemical performance. Such a well-designed Li-MMT SEI not only possesses inherent fast lithium-ion channels, but also works as a reservoir to supply adequate lithium-ions in the interlaminations and periphery of Li-MMT nanosheets, offering fast lithiumion transfer in interlaminations and sheet-to-sheet. Furthermore, the strong trend of lithium-ion absorption of Li-MMT is confirmed by density functional theory calculations and stable lithium deposition under Li-MMT SEI layer at 10 mA cm −2 is verified via finite element modeling. As a result, a steady lithium deposition process without dendrites is achieved. Coulombic efficiency of the half-cell accomplishes a mean value of 99.1% over 400 cycles at 1 mA cm −2 , while Li-LiFePO 4 full cells show a stable capacity up to 120 mAh g −1 and steady circulation over 400 loops at 1C. This work offers a novel strategy to design a high-performance SEI layer and suppress dendrite growth.
Rheumatoid arthritis (RA) severely threatens human health
by causing
inflammation, swelling, and pain in the joints and resulting in persistent
synovitis and irreversible joint disability. In the development of
RA, pro-inflammatory M1 macrophages, which express high levels of
reactive oxygen species (ROS) and nitric oxide (NO), induce synovial
inflammation and bone erosion. Eliminating ROS and NO in the inflamed
joints is a potential RA therapeutic approach, which can drive the
transition of pro-inflammatory M1 macrophages to the anti-inflammatory
M2 phenotype. Taking advantage of the intrinsic ROS- and NO-scavenging
capability of DNA molecules, herein, we report the development of
folic acid-modified triangular DNA origami nanostructures (FA-tDONs)
for targeted RA treatment. FA-tDONs could efficiently scavenge ROS
and NO and actively target M1 macrophages, facilitating the M1-to-M2
transition and the recovery of associated cytokines and biomarkers
to the normal level. The therapeutic efficacy of FA-tDONs was examined
in the RA mouse model. As validated by appearance, histological, and
serum examinations, FA-tDONs treatment effectively alleviated synovial
infiltration and cartilage damage, attenuating disease progression.
This study demonstrated the usage of DNA origami for RA treatment
and suggested its potential in other antioxidant therapies.
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