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We developed highly dispersible and photostable nanoparticles of vitamin, folic acid (FA). FA was wet bead milled with milling and dispersing adjuvants and transglycosylated compounds such as α-glucosyl hesperidin (Hesperidin-G) and rutin (Rutin-G), which solubilized FA. The milled slurries of FA particles with transglycosylated compounds consisted of nanosized particles with a median diameter of <100 nm. The lyophilized formulations of these slurries retained their nanometer size after resuspension in water with no aggregation. The apparent solubility of FA in these formulations was 100-fold higher than that of untreated FA. The solubilizing effect of Rutin-G may affect the particle size reduction and dispersibility of FA. The photostability results showed that the strong antioxidant activity of Rutin-G substantially increased the photostability of FA solution. On the basis of these results, bead milling of FA with Rutin-G is a promising technique for developing highly dispersible, photostable nanoparticle FA formulations.

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The surface charge of metal oxides in the solution phase may be a driving force for crystallization. Composite particles were prepared using the principle of heterogeneous nucleation on a metal surface with varying charge density. The electrical properties of the silica gel particles in an electrolyte solution were controlled by the pH, and the zero charge point and charge density of the silica gel particles were determined by titration. The morphology of the glycine particles on the silica gel surface depended on the electrical properties of the silica gel particle, resulting in alteration of the glycine polymorph. Powder X‐ray diffraction showed that γ‐glycine was present at low pH, and α‐glycine, at high pH. The polymorphism arose from the abundance ratio of the solute ions and the solution structure.

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