Fabrication of composite particles by liquid–liquid interfacial crystallization using an ultrasonic spray nozzle

Gonda, Kazuki; Kadota, Kazunori; Deki, Yuto; Tozuka, Yuichi; Shimosaka, Atsuko; Shirakawa, Yoshiyuki; Hidaka, Jusuke

doi:10.1016/j.powtec.2014.09.042

Cited by 16 publications

(6 citation statements)

References 36 publications

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“…Because this method does not require thermal energy and can suppress supersaturation fluctuations by limiting the crystal precipitation field to the liquid-liquid interface, it could be applied to a wide range of materials. We have controlled crystal morphology by changing parameters such as organic solvent species, contact time, and solute concentration [18][19][20], and we have prepared composite particles from multicomponent solutions [21]. Therefore, this method may be suitable for producing particles instead of crystallization methods such as evaporation, cooling, and anti-solvent addition.…”

Section: Introductionmentioning

confidence: 99%

Mutual diffusion diagram of liquid-liquid interfaces for morphological control of NaCl crystals

Deki

Kadota

Tozuka

et al. 2016

Journal of Molecular Liquids

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Section: Introductionmentioning

confidence: 99%

Mutual diffusion diagram of liquid-liquid interfaces for morphological control of NaCl crystals

Deki

Kadota

Tozuka

et al. 2016

Journal of Molecular Liquids

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“…Generally, crystal polymorphism strongly depends on the environment during precipitation (e.g., solvent, temperature, impurities). We previously reported that the crystal polymorphism of glycine depended on the operating time, the temperature, and the supersaturation ratio . Because the amount of charge on the silica gel particles was small enough that it did not attract the solute and the saturation concentration of glycine was high at low pH (Figs.…”

Section: Resultsmentioning

confidence: 99%

Crystallization Behavior of Glycine Molecules with Electrolytic Dissociation on Charged Silica Gel Particles

et al. 2018

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The surface charge of metal oxides in the solution phase may be a driving force for crystallization. Composite particles were prepared using the principle of heterogeneous nucleation on a metal surface with varying charge density. The electrical properties of the silica gel particles in an electrolyte solution were controlled by the pH, and the zero charge point and charge density of the silica gel particles were determined by titration. The morphology of the glycine particles on the silica gel surface depended on the electrical properties of the silica gel particle, resulting in alteration of the glycine polymorph. Powder X‐ray diffraction showed that γ‐glycine was present at low pH, and α‐glycine, at high pH. The polymorphism arose from the abundance ratio of the solute ions and the solution structure.

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“…We introduced the synthesis of organic-organic composite particles by using an ultrasonic spray nozzle in the interfacial crystallization. Glycine and starch were selected as model substances for the process (Gonda et al, 2015). Glycine and starch are commonly used as a model drug for pharmaceutical products and as an excipient, respectively.…”

Section: Synthesis Of Organic-organic Composite Particles In a Spray mentioning

confidence: 99%

“…SEM photographs of composite particles of starch with glycine prepared by ultrasonic spray nozzle: (a) composite particles; (b) cross section of composite particle framed by dot-line is the starch of the core particle. Reprinted with permission from Ref (Gonda et al, 2015)…”

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confidence: 99%

Particle Preparation and Morphology Control with Mutual Diffusion Across Liquid-Liquid Interfaces

Kadota

Shirakawa

2021

KONA

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Advanced functional materials require sophisticated control of particle characteristics. The bottom-up process has been extensively used to produce functional materials for controlling the particle properties of composite particles. We propose crystallization at liquid-liquid interfaces as an advanced particle formation method. This review introduces crystallization at a liquid-liquid interface based on several case studies used in various applications. Conventional crystallization has been generally used to produce crystals and particles with homogeneous particle properties. Liquid-liquid interfacial crystallization makes it possible to create composite particles with hetero-phase structures and interfaces. Liquid-liquid interfacial crystallization with an inkjet technique can control the droplet size accurately, and the shape and particle size distribution are successfully controlled in inorganic-organic composite particles. In addition, we succeed in creating organic-organic composite particles using the interfacial crystallization by an ultrasonic spray nozzle. The coating efficiency of organic particles on the particles is enhanced using the ultrasonic spray nozzle in comparison with anti-solvent crystallization. In this study, the fabrication of inorganic-organic composite particles using a coaxial tube reactor on the liquid-liquid interfacial crystallization is proven successful. These findings suggest that liquid-liquid interfacial crystallization is a promising means of efficiently producing composite particles because of their applicability to infusion in various processes.

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Fabrication of composite particles by liquid–liquid interfacial crystallization using an ultrasonic spray nozzle

Cited by 16 publications

References 36 publications

Mutual diffusion diagram of liquid-liquid interfaces for morphological control of NaCl crystals

Mutual diffusion diagram of liquid-liquid interfaces for morphological control of NaCl crystals

Crystallization Behavior of Glycine Molecules with Electrolytic Dissociation on Charged Silica Gel Particles

Particle Preparation and Morphology Control with Mutual Diffusion Across Liquid-Liquid Interfaces

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