Mutual diffusion diagram of liquid-liquid interfaces for morphological control of NaCl crystals

Deki, Yuto; Kadota, Kazunori; Tozuka, Yuichi; Shimosaka, Atsuko; Shirakawa, Yoshiyuki

doi:10.1016/j.molliq.2016.08.071

Cited by 9 publications

(5 citation statements)

References 35 publications

(38 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, the ATC molecules of the imaged precipitate also distributed around the droplet boundary externally and internally, as presented in Figure c–e, respectively. This correspondence between the precipitation zones and the dominant distribution areas of ATC molecules also conforms to prior studies on sodium chloride . Obviously, regarding the dimensions of the molecules, the geometric volume of the ATC molecule was significantly larger than that of methanol or the water molecule.…”

Section: Resultssupporting

confidence: 88%

“…This correspondence between the precipitation zones and the dominant distribution areas of ATC molecules also conforms to prior studies on sodium chloride. 42 Obviously, regarding the dimensions of the molecules, the geometric volume of the ATC molecule was significantly larger than that of methanol or the water molecule. However, this key distinction also impairs its diffusion capability, resulting in a notably lower migration velocity compared with those of the lighter compounds.…”

Section: Droplet Evolution and Precipitation Region Inmentioning

confidence: 99%

See 1 more Smart Citation

Crystal Agglomeration and Microscopic Molecular Exchange Mechanism in Antisolvent Crystallization

Qin,

Yang

2024

Crystal Growth & Design

View full text Add to dashboard Cite

Agglomeration is a significant challenge in antisolvent crystallization, especially when it comes to crystallizing insoluble drugs. This study aimed to address this issue by taking a unique, dynamic molecular perspective and proposing a solution based on microscopic molecular exchange. Atorvastatin calcium, a widely prescribed medication for lowering blood lipids, was used as a case for antisolvent crystallization, which is also prone to agglomeration. Kinetic experiments revealed the rapid exchange between solvent and antisolvent, leading to precipitation occurring within a mere 0.0333 s. Thermodynamic investigations further showed that each droplet had the potential to generate an astonishing equivalent nucleation rate of up to 5 billion nuclei per second. The rapid precipitation and small nucleation region, coupled with a large number of nuclei, worsened the crystal agglomeration problem. However, it was found that this molecular exchange process can be slowed by the solvent composition. Specifically, when the methanol mole fraction in the crystallization system reached approximately 50%, the equivalent nucleation rate decreased significantly to about 100 million per second. Armed with this crucial finding, a strategy was devised to overcome agglomeration by simultaneously adding the solution and antisolvent to maintain a lower exchange rate, which effectively avoided agglomeration and promoted the purification of atorvastatin calcium.

show abstract

Section: Resultssupporting

confidence: 88%

Section: Droplet Evolution and Precipitation Region Inmentioning

confidence: 99%

Crystal Agglomeration and Microscopic Molecular Exchange Mechanism in Antisolvent Crystallization

Qin,

Yang

2024

Crystal Growth & Design

View full text Add to dashboard Cite

show abstract

“…The formation of three different morphologies may be related to the different crystal growth interfaces. The 3D "silk flowers" shaped LDH particles grow on the interface between liquid-liquid interfaces [60,61] (water and BuOH) ( Fig. S3a), and "sedimentary rock" shaped LDH particles grow on the solid-liquid interface [62] (Fig.…”

Section: Characterization Of Znal-ldhsmentioning

confidence: 99%

Water–n-BuOH solvothermal synthesis of ZnAl–LDHs with different morphologies and its calcined product in efficient dyes removal

Huang

Sun

Zhao

et al. 2017

Journal of Colloid and Interface Science

View full text Add to dashboard Cite

In this study, water-n-BuOH mixed solvents were used to synthesize the ZnAl-layered double hydroxides (ZnAl-LDHs) via hydrothermal method. The XRD, FT-IR, SEM, ICP and CHN analyses revealed that the type of intercalated anions, the layer Zn/Al ratios, and morphologies of the LDHs depended on the ratio of V(water)/V(n-BuOH) in the mixed solvents. When the ratio of V(water)/V(n-BuOH) is 3 or 0.3, the as-prepared LDHs had 3D "silk flowers" (ZnAl-LDH-3) or "Sedimentary rock" morphology (ZnAl-LDH-0.3). Adsorption properties of dyes on calcined LDHs were studied. Compared with ZnAl-LDO-0.3 and ZnAl-LDO-w (calcined from the LDHs obtained in pure water), ZnAl-LDO-3 showed much better adsorption efficiency for anionic dyes thanks to its much larger BET-specific surface area. The sorption kinetics for dyes was appropriately described by the pseudo-second-order model and sorption isotherms can be fitted more satisfactorily by the Langmuir model. With the increasing concentrations of dyes from 10mg/L to 400mg/L, the maximum absorption capacities of ZnAl-LDO-3 were 1540mg/g (2.21mmol/g) for congo red, 1153mg/g (3.52mmol/g) for methyl orange and 390mg/g (0.63mmol/g) for active red (X-3B), respectively. The adsorption dyes onto the external surface is still the main mechanism for LDO adsorbents. The ZnAl-LDO-3 was a potential adsorbent for dyeing wastewater treatment.

show abstract

“…The difference in surface morphology derives from the mutual diffusion behavior following the organic solvent. Phase diagrams of water/1-butanol and /2butanone were previously reported (Kitayama et al, 2009b;Kadota et al, 2013;Deki et al, 2016). In the solubility of 1-butanol in water, the amount of water diffusing into 1-butanol was much greater than that of 1-butanol diffusing into water at 25 °C.…”

Section: Crystallization At Liquid-liquid Interfacementioning

confidence: 76%

Particle Preparation and Morphology Control with Mutual Diffusion Across Liquid-Liquid Interfaces

Kadota

Shirakawa

2021

KONA

Self Cite

View full text Add to dashboard Cite

Advanced functional materials require sophisticated control of particle characteristics. The bottom-up process has been extensively used to produce functional materials for controlling the particle properties of composite particles. We propose crystallization at liquid-liquid interfaces as an advanced particle formation method. This review introduces crystallization at a liquid-liquid interface based on several case studies used in various applications. Conventional crystallization has been generally used to produce crystals and particles with homogeneous particle properties. Liquid-liquid interfacial crystallization makes it possible to create composite particles with hetero-phase structures and interfaces. Liquid-liquid interfacial crystallization with an inkjet technique can control the droplet size accurately, and the shape and particle size distribution are successfully controlled in inorganic-organic composite particles. In addition, we succeed in creating organic-organic composite particles using the interfacial crystallization by an ultrasonic spray nozzle. The coating efficiency of organic particles on the particles is enhanced using the ultrasonic spray nozzle in comparison with anti-solvent crystallization. In this study, the fabrication of inorganic-organic composite particles using a coaxial tube reactor on the liquid-liquid interfacial crystallization is proven successful. These findings suggest that liquid-liquid interfacial crystallization is a promising means of efficiently producing composite particles because of their applicability to infusion in various processes.

show abstract

Mutual diffusion diagram of liquid-liquid interfaces for morphological control of NaCl crystals

Cited by 9 publications

References 35 publications

Crystal Agglomeration and Microscopic Molecular Exchange Mechanism in Antisolvent Crystallization

Crystal Agglomeration and Microscopic Molecular Exchange Mechanism in Antisolvent Crystallization

Water–n-BuOH solvothermal synthesis of ZnAl–LDHs with different morphologies and its calcined product in efficient dyes removal

Particle Preparation and Morphology Control with Mutual Diffusion Across Liquid-Liquid Interfaces

Contact Info

Product

Resources

About