According to the literature, negations such as "not" or "don't" reduce the accessibility in memory of the concepts under their scope. Moreover, negations applied to action contents (e.g., "don't write the letter") impede the activation of motor processes in the brain, inducing "disembodied" representations. These facts provide important information on the behavioral and neural consequences of negations. However, how negations themselves are processed in the brain is still poorly understood. In two electrophysiological experiments, we explored whether sentential negation shares neural mechanisms with action monitoring or inhibition. Human participants read action-related sentences in affirmative or negative form ("now you will cut the bread" vs "now you will not cut the bread") while performing a simultaneous Go/NoGo task. The analysis of the EEG rhythms revealed that theta oscillations were significantly reduced for NoGo trials in the context of negative sentences compared with affirmative sentences. Given the fact that theta oscillations are often considered as neural markers of response inhibition processes, their modulation by negative sentences strongly suggests that negation uses neural resources of response inhibition. We propose a new approach that views the syntactic operator of negation as relying on the neural machinery of high-order action-monitoring processes.

The two-step process account of negation understanding posits an initial representation of the negated events, followed by a representation of the actual state of events. On the other hand, behavioral and neurophysiological studies provided evidence that linguistic negation suppresses or reduces the activation of the negated events, contributing to shift attention to the actual state of events. However, the specific mechanism of this suppression is poorly known. Recently, based on the brain organization principle of neural reuse ( Anderson, 2010 ), it has been proposed that understanding linguistic negation partially relies upon the neurophysiological mechanisms of response inhibition. Specifically, it was reported that negated action-related sentences modulate EEG signatures of response inhibition ( de Vega et al., 2016 ; Beltrán et al., 2018 ). In the current EEG study, we ponder whether the reusing of response inhibition processes by negation is constrained to action-related contents or consists of a more general-purpose mechanism. To this end, we employed the same dual-task paradigm as in our prior study—a Go/NoGo task embedded into a sentence comprehension task—but this time including both action and non-action sentences. The results confirmed that the increase of theta power elicited by NoGo trials was modulated by negative sentences, compared to their affirmative counterparts, and this polarity effect was statistically similar for both action- and non-action-related sentences. Thus, a general-purpose inhibitory control mechanism, rather than one specific for action language, is likely operating in the comprehension of sentential negation to produce the transition between alternative representations.

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It is generally accepted that empathy should be the basis of patient care. However, this ideal may be unrealistic if healthcare professionals suffer adverse effects when engaging in empathy. The aim of this study is to explore the effect of inferring mental states and different components of empathy (perspective-taking; empathic concern; personal distress) in burnout dimensions (emotional exhaustion; depersonalization; personal accomplishment). A total of 184 healthcare professionals participated in the study (23% male, Mage = 44.60; SD = 10.46). We measured participants’ empathy, the inference of mental states of patients, and burnout. Correlation analyses showed that inferring mental states was positively associated with perspective-taking and with empathic concern, but uncorrelated with personal distress. Furthermore, emotional exhaustion was related to greater levels of personal distress and greater levels of inferences of mental states. Depersonalization was associated with greater levels of personal distress and lower levels of empathic concern. Personal accomplishment was associated with the inference of mental states in patients, lower levels of personal distress, and perspective-taking. These results provide a better understanding of how different components of empathy and mental state inferences may preserve or promote healthcare professionals’ burnout.

Background Processing of linguistic negation has been associated to inhibitory brain mechanisms. However, no study has tapped this link via multimodal measures in patients with core inhibitory alterations, a critical approach to reveal direct neural correlates and potential disease markers. Methods Here we examined oscillatory, neuroanatomical, and functional connectivity signatures of a recently reported Go/No-go negation task in healthy controls and behavioral variant frontotemporal dementia (bvFTD) patients, typified by primary and generalized inhibitory disruptions. To test for specificity, we also recruited persons with Alzheimer's disease (AD), a disease involving frequent but nonprimary inhibitory deficits. Results In controls, negative sentences in the No-go condition distinctly involved frontocentral delta (2–3 Hz) suppression, a canonical inhibitory marker. In bvFTD patients, this modulation was selectively abolished and significantly correlated with the volume and functional connectivity of regions supporting inhibition (e.g. precentral gyrus, caudate nucleus, and cerebellum). Such canonical delta suppression was preserved in the AD group and associated with widespread anatomo-functional patterns across non-inhibitory regions. Discussion These findings suggest that negation hinges on the integrity and interaction of spatiotemporal inhibitory mechanisms. Moreover, our results reveal potential neurocognitive markers of bvFTD, opening a new agenda at the crossing of cognitive neuroscience and behavioral neurology.

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Abstract:In two experiments we investigated the role that activation of emotional inferences when readers represent fictional characters' emotional states using an affective lexical decision task. Subjects read short stories that described concrete actions. In the first experiment, we analyzed whether the valence (positive or negative) was an important factor of inference´s activation. The results showed that valence was determinant factor in the moment that emotional inference was generated, being the positive valence faster than negative. In the second experiment we studied whether the emotion inference activation was influenced by the causal direction of the story, where the causal direction of the text was manipulated in order to induce towards an emotional inference predictive (the reader looking for a consequence that promote a particular emotion) or inducing an explanatory inference (reader looking for a cause that "explain" a particular emotion). The results suggest that emotional inferences are made online, and that valence and causal directions are two decisive components of emotional trait, but only positive valence increase their processing. Key words: Emotional inferences; emotional valence; causal direction; lexical decision task; explanatory inference: predictive inference.Título: Efectos de la valencia y la dirección causal en el procesamiento de inferencias emocionales durante la lectura: Evidencia mediante una tarea de decisión léxica. Resumen: En dos experimentos se investigó el papel que juega la activación de inferencias emocionales cuando los lectores representan estados emocionales de los personajes ficticios mediante una tarea de decisión léxi-ca. Los participantes leyeron historias cortas que describían acciones concretas. En el primer experimento se analizó si la valencia emocional (positiva o negativa) influía en la activación de la inferencia. Los resultados mostraron que la valencia fue factor determinante en el momento en que generaba la inferencia emocional, siendo la valencia positiva más rápida que la negativa. En el segundo experimento se analizó la dirección causal de la historia, donde en un caso fue manipulada para inducir hacia una inferencia emocional predictiva (el lector busca una acción que anticipa una emoción particular), y en otro explicativa (el lector busca una causa que "explique" una emoción en particular) y si estas dos condiciones diferían en la activación de la inferencia emocional. Los resultados revelaron que las inferencias emocionales se hacen de manera automática en ambos estudios y que tanto la valencia como la dirección causal se consideran componentes básicos de las inferencias emocionales, pero sólo la valencia positiva acelera aún más el procesamiento del rasgo emocional.