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It is not known whether this protection is due to the accumulation of a substance that competes with TMPP for active sites on cholinesterase, to a change in membrane permeability barring the entrance of TMPP into esterado sites, or to the failure of the circulatory system to transport TMPP through the body.The in vivo protection against TMPP may also be cited as an example of a reversible phenomenon. DDT-prostrate cockroaches tolerated an injected dosage of TMPP that inhibited 90% of the cholinesterase of a normal cockroach, but if the DDT-prostrate cockroaches were allowed to recover even briefly by raising the temperature before injection of TMPP, no protection occurred.

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