Pesticide Metabolism, Fate of Aldrin and Dieldrin in the Animal Body

Bann, J. M.; DeCino, T. J.; Earle, N. W.; Sun, Yun-Pei

doi:10.1021/jf60069a003

Cited by 79 publications

(22 citation statements)

References 5 publications

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“…The conversion results in a material that, in addition to being highly toxic to insects, has much greater residual properties than the parent material(S). Aldrin has also been shown to be converted to dieldrin in animals as well as in soils and plants (7). Therefore, the toxicity of dieldrin, as well as that of aldrin, is pertinent to a discussion of these materials in terms of residue levels found in this study.…”

Section: Toxiological Factorsmentioning

confidence: 89%

Environmental Effects of Termite Control Insecticides

Barnes¹,

Shaheen²

1966

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Section: Toxiological Factorsmentioning

confidence: 89%

Environmental Effects of Termite Control Insecticides

Barnes¹,

Shaheen²

1966

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“…Gowdey et al (1952) showed that aldrin augmented the reflex activity of the spinal cord and the excitability of spinal centres to acetylcholine and pentylenetetrazol (Metrazol). Aldrin is rapidly converted to dieldrin in the animal body and the effects of aldrin will therefore also hold good for dieldrin (Giannotti et al, 1956;Bann et al, 1965;Brooks, 1960). That dieldrin increases sensitivity to pentylene-tetrazol was confirmed also by Natoff and Reiff (1967).…”

Section: Introductionmentioning

confidence: 86%

Excitatory and depressant effects of dieldrin and aldrin-transdiol in the spinal cord of the toad (Xenopus laevis)

Akkermans

Bercken

Versluijs-Helder

1975

European Journal of Pharmacology

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L.M.A. AKKERMANS, J. VAN DEN BERCKEN and M. VERSLUIJS-HELDER, Excitatory and depressant effects of dieldrin and aldrin-transdiol in the spinal cord of the toad (Xenopus laevis), European J. Pharmacol. 34 (1975) 133--142. An investigation was made into the action of the insecticide dieldrin and one of its metabolites, aldrin-transdiol, on the isolated spinal cord of the toad, Xenopus laevis. Conventional electrophysiological techniques were used for stimulating and recording of dorsal and ventral spinal roots. An augmentation of polysynaptic reflex activity along with a marked reduction of orthodromic postsynaptic inhibition could be demonstrated in preparations isolated from dieldrin-poisoned animals. However, application of dieldrin to the isolated spinal cord failed to produce any significant effect. Application of aldrin-transdiol, on the other hand, caused a potentiation of spinal reflex activity and an increase in spontaneous activity of ventral and dorsal roots. Aldrin-transdiol also produced a marked reduction of spinal inhibitory mechanisms. The excitatory effects of aldrin-transdiol were followed by a strong depressant action on spinal excitability. Isolated spinal cord Postsynaptic inhibition Spinal root potentials Presynaptic inhibition DieldrinAldrin-transdiol

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“…The bioassay of aldrin-treated animals gave dramatically higher bioassay residues in the fat of rat, sheep, pig, and beef than residues determined by a colorimetric aldrin procedure. Dieldrin does not respond to this colorimetric test, The animal fats contained a toxic metabolite, later identified as dieldrin (BANN et al 1956). …”

Section: D) Intoxification and Detoxificationmentioning

confidence: 96%

Bioassay as a monitoring tool

Kohn

1980

Residue Reviews

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Pesticide Metabolism, Fate of Aldrin and Dieldrin in the Animal Body

Cited by 79 publications

References 5 publications

Environmental Effects of Termite Control Insecticides

Environmental Effects of Termite Control Insecticides

Excitatory and depressant effects of dieldrin and aldrin-transdiol in the spinal cord of the toad (Xenopus laevis)

Bioassay as a monitoring tool

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