Synergistic and Antagonistic Actions of Insecticide-Synergist Combinations and Their Mode of Action

Sun, Yun-Pei; Johnson, E. R.

doi:10.1021/jf60110a003

Cited by 147 publications

(57 citation statements)

References 1 publication

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“…The biochemical assays indicate elevated levels of all three of the major detoxification enzyme families in the Cayman Islands population relative to the New Orleans strain. However, pre-exposure to the synergist PBO, which acts as a general inhibitor of cytochrome P450s and esterases, 24,25 did not significantly increase the level of permethrin-induced mortality. This synergist data suggest that enhanced metabolism is not a major cause of permethrin resistance in this population and it is possible that the elevated levels of P450 observed may be caused by differences between the Cayman and New Orleans strains that are unrelated to their resistance status.…”

Section: Discussionmentioning

confidence: 82%

Pyrethroid Resistance in Aedes aegypti from Grand Cayman

Harris¹,

Rajatileka²,

Ranson³

2010

The American Society of Tropical Medicine and Hygiene

227

236

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The Grand Cayman population of Aedes aegypti is highly resistant to DDT and pyrethroid insecticides. Glutathione transferase, cytochrome P450, and esterase levels were increased in the Grand Cayman population relative to a susceptible laboratory strain, but synergist studies did not implicate elevated insecticide detoxification as a major cause of resistance. The role of target site resistance was therefore investigated. Two substitutions in the voltage-gated sodium channel were identified, V1016I in domain II, segment 6 (IIS6) (allele frequency = 0.79) and F1534C in IIIS6 (allele frequency = 0.68). The role of the F1534C mutation in conferring resistance to insecticides has not been previously established and so a tetraplex polymerase chain reaction assay was designed and used to genotype mosquitoes that had been exposed to insecticides. The F1534C mutation was strongly correlated with resistance to DDT and permethrin.

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Section: Discussionmentioning

confidence: 82%

Pyrethroid Resistance in Aedes aegypti from Grand Cayman

Harris¹,

Rajatileka²,

Ranson³

2010

The American Society of Tropical Medicine and Hygiene

227

236

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“…Shaaban and Al Mallah (1993), Sun and Johnson (1960). Reported that The synergies mainly depends on the materials that may be motivating or inhibitory the enzymes and thus on the chemical composition of pesticides.…”

Section: Results and Discssionmentioning

confidence: 99%

Effect of mixing ratio and oil kind on toxicity activation of Acetamprid against Trogoderma granarium larvae

Karso¹

2014

iosrphr

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“…The co-toxicity coefficient per P. glandulosus leaf powder-H. acida wood ash mixture was calculated: A co-toxicity coefficient of less than 80 is considered as antagonistic, between 80 and 120 as additive and higher than 120 as synergistic [26]. When mixture (M) compounds of two parts (A and B) and both components have LC 50 , then the following formulae are used (A serving as standard, it is represented in this study by P. glandulosus leaf powder, B represents wood ash for H. acida):…”

Section: Toxicity Bioassaymentioning

confidence: 99%

Effectiveness of binary combinations of Plectranthus glandulosus leaf powder and Hymenocardia acida wood ash against Sitophilus zeamais (Coleoptera: Curculionidae)

et al. 2018

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Background: Botanicals are generally assumed to be more biodegradable, leading to less environmental problems. Combination of botanicals could enhance biological activity against insect pests. Hence, the amount of botanical used for the control of stored grain pests may be minimised. In this study, the bioassay was carried out on Sitophilus zeamais to assess the effectiveness of binary combinations of Hymenocardia acida wood ash and Plectranthus glandulosus leaf powder. The quantities of mixed products were added to maize grains to constitute the contents of 5, 10, 20 and 40 g/kg. Then, the bioassays on toxicity within 1, 3, 7 and 14 days exposure, progeny production, population increase, grain damage and germination ability of protected grains were carried out. Results:The major compounds (pinene, α-pinene, α-terpineol, thymol, β-myrcene and 3-carene) of P. glandulosus leaf powder were monoterpenes. The major non-monoterpenic constituent was an oxygenated sesquiterpene, β caryophyllene oxide. The chemical analysis of H. acida ash showed that calcium (5800 mg/kg) and phosphorus (2782 mg/kg) recorded higher content than the other minerals. Plectranthus glandulosus leaf powder, H. acida wood ash and their binary combinations significantly induced mortality of S. zeamais adult (P < 0.0001). The higher mortality rate was achieved by the highest content within 14 days of exposure. The combinations of P. glandulosus leaf powder with H. acida at different proportions produced different interactions. The mixture of 75% P. glandulosus and 25% H. acida produced synergistic effect, whereas the mixture of 50:50 had antagonistic effect in weevil mortality. The three combinations of H. acida and P. glandulosus significantly reduced the production of the progeny compared to the control. From the application of 5 g/kg (lowest content), the number of emerging adults was highly reduced. The combination 25PG75HA revealed to be more effective than the two other against F 1 production. The grain damage and population growth were significantly reduced. In general, the non-infested maize grain had a good germination rate than the infested ones. The treatment did not have negative effect on seed germination. Conclusions:From our results, the two powders and their binary combinations could be used to reduce grain infestation by insect while taking into account the proportions of insecticidal powders implied in the combination.

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Synergistic and Antagonistic Actions of Insecticide-Synergist Combinations and Their Mode of Action

Cited by 147 publications

References 1 publication

Pyrethroid Resistance in Aedes aegypti from Grand Cayman

Pyrethroid Resistance in Aedes aegypti from Grand Cayman

Effect of mixing ratio and oil kind on toxicity activation of Acetamprid against Trogoderma granarium larvae

Effectiveness of binary combinations of Plectranthus glandulosus leaf powder and Hymenocardia acida wood ash against Sitophilus zeamais (Coleoptera: Curculionidae)

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