In this study, Tanshinone IIA lipid microspere (Tan-IIA-LM) was successfully prepared by an ultrasonic and high-pressure homogenization method. The particle size, zeta potential, drug entrapment efficiency and morphological properties of Tan-IIA-LM were characterized in detail. A pharmacokinetic comparative study of Tan-IIA-LM with Sodium Tanshinone IIA Silate (STS) injection was developed. A sensitive and specific HPLC method was established to determine the mass concentration of Tan-IIA and STS in rats plasma samples which were compared between Tan-IIA-LM and STS injection after single dose intravenous administration of 18.35μmol/kg and the results were fitted and analyzed by dedicated software. After intravenous administration, the AUC0-and Cmaxvalues of Tan-IIA were 2.14, 2.22 fold higher than STS. The clearance, apparent volume of distribution and mean residence time (MRT) of Tan-IIA were lower (P<0.01) than STS; other pharmacokinetic parameters had no significant deviation (P>0.05). The pharmacokinetic of Tan-IIA, STS have significant differences at the same molar doses and the AUC and Cmaxvalues of Tan-IIA were higher compared with STS.
Compare investigate physicochemical properties of fine powder and two ultrafine powders of Dragon’s Blood, and then to determinate particle size distribution for ultrafine powders of Dragon’s Blood. Specific surface area and porosity, surface morphology and moisture absorption of Dragon’s Blood powders were investigated. The content and the in vitro dissolution of dracorhodin in Dragon’s Blood powders were determined by HPLC. The results showed that the content of dracorhodin had no significant difference among three Dragon’s Blood powders. With the decreasing of particle size the degree of moisture decreased. The dissolution of dracorhodin in the order of: ultrafine powder I > ultrafine powder II > fine powder. An appropriate degree of superfine grinding can improve moisture absorption of Dragon’s Blood powders and dissolution of dracorhodin. Particle size distribution of Dragon’s Blood ultrafine powder should be controlled about 40 μm.
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