Cardiocerebral vascular diseases (CCVDs) are the main reasons for high morbidity and mortality all over the world, including atherosclerosis, hypertension, myocardial infarction, stroke, and so on. Chinese herbs pair of the Cinnamomum cassia Presl (Chinese name, rougui) and the Aconitum carmichaelii Debx (Chinese name, fuzi) can be effective in CCVDs, which is recorded in the ancient classic book Shennong Bencao Jing, Mingyibielu and Thousand Golden Prescriptions. However, the active ingredients and the molecular mechanisms of rougui-fuzi in treatment of CCVDs are still unclear. This study was designed to apply a system pharmacology approach to reveal the molecular mechanisms of the rougui-fuzi anti-CCVDs. The 163 candidate compounds were retrieved from Traditional Chinese Medicine System Pharmacology Database and Analysis Platform (TCMSP). And 84 potential active compounds and the corresponding 42 targets were obtained from systematic model. The underlying mechanisms of the therapeutic effect for rougui-fuzi were investigated with gene ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Then, component-target-disease (C-T-D) and target-pathway (T-P) networks were constructed to further dissect the core pathways, potential targets, and active compounds in treatment of CCVDs for rougui-fuzi. We also constituted protein-protein in interaction (PPI) network by the reflect target protein of the crucial pathways against CCVDs. As a result, 21 key compounds, 8 key targets, and 3 key pathways were obtained for rougui-fuzi. Afterwards, molecular docking was performed to validate the reliability of the interactions between some compounds and their corresponding targets. Finally, UPLC-Q-Exactive-MSE and GC-MS/MS were analyzed to detect the active ingredients of rougui-fuzi. Our results may provide a new approach to clarify the molecular mechanisms of Chinese herb pair in treatment with CCVDs at a systematic level.
Compare investigate physicochemical properties of fine powder and two ultrafine powders of Dragon’s Blood, and then to determinate particle size distribution for ultrafine powders of Dragon’s Blood. Specific surface area and porosity, surface morphology and moisture absorption of Dragon’s Blood powders were investigated. The content and the in vitro dissolution of dracorhodin in Dragon’s Blood powders were determined by HPLC. The results showed that the content of dracorhodin had no significant difference among three Dragon’s Blood powders. With the decreasing of particle size the degree of moisture decreased. The dissolution of dracorhodin in the order of: ultrafine powder I > ultrafine powder II > fine powder. An appropriate degree of superfine grinding can improve moisture absorption of Dragon’s Blood powders and dissolution of dracorhodin. Particle size distribution of Dragon’s Blood ultrafine powder should be controlled about 40 μm.
Solid dispersions (SD) were prepared with naringenin and polyvinyl pyrrolidone k-30 (PVP k-30) by the solvent evaporation method with three drying methods (microwave-vacuum drying, MVD; and spray drying, SPD; vacuum drying, VD). The physical state was characterized by DSC, PXRD, SEM, and FT-IR. The results showed that the vitro dissolution rate and extent of naringenin was improved significantly by SD as compared with the pure drug and physical mixtures (PM). The results of FT-IR showed that naringenin is possibly interacted with PVP k-30 via intermolecular hydrogen bond, the results of DSC and PXRD showed that all of the SD prepared with three drying methods was completely amorphous. Compared with other drying methods, the MVD method can save time and energy. The physical state of SD prepared with the three drying methods that stored in the 40 °C/75% RH chamber was stable in three month. These results suggest that MVD is feasible to replace the traditional time-consuming and low efficiency drying procedure for preparation of SD.
The aim of the present study was to increase bioavailability after oral administration. In this study, Panaxnotoginseng saponins (PNS) was entrapped within the long-circulating nanoparticles (LCNs) by the multiple emulsion method. The PNS-LCNs were characterized in terms of size, zeta potential, morphology, thermal properties, drug entrapment efficiency (EE), and in vitro release of the PNS. In addition, the intestinal absorption of PNS-LCNs in vitro was investigated. The pharmacokinetics of PNS-LCNs following oral administration was determined over 72 h in male rats. It was found that the mean particle size and zeta potential of the PNS-LCNs were 147±4.5nm and −44.7±1.5mV, respectively, and the entrapment efficiency (EE) was 53.93%±0.69%. differential scanning calorimetry (DSC) indicated that PNS has different states in PNS-LCNs and original PNS. The release pattern of the PNS-LCNs followed the Weibull model. The release parameters (T50, TD) were observed to be higher for PNS-LCNs compared with original PNS (p< 0.01) in vitro release. The intestinal absorption study indicated that the intestinal permeability coefficient (Papp) of PNS-LCNs was higher than original PNS’s. The pharmacokinetics of PNS-LCNs was studied after oral administration to male rats, PNS-LCNs provided greater area under the concentration-time curve (AUC), higher plasma concentration (Cmax), longer mean residence time (MRT) and median time to maximum drug concentration (Tmax). LCNs could be used for improving permeability and increased bioavailability after oral administration of PNS.
For the request of electric vehicle on drive motor, the permanent magnet synchronous motor (PMSM) get more and more attention by its small size and torque characteristics. By analyzing the traction motor characteristics with a constant torque starting and constant power operation, the space vector pulse width modulation (SVPWM) algorithm is used to replace the switching table for direct torque control (DTC) strategy. By analyzing the mathematical model of the PMSM, for the existence of permanent magnets, the rotor coordinate system is applied when calculating the stator flux. Meanwhile, the electric vehicle starting block and the brake block are simulated for the characteristics of that walk namely stop. The results show that the speed has a smooth transition and the torque has a quick response.
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