“…[9] Naringenin has a reported aqueous solubility of 45 mg/ml (37°C, pH 3) [10] and quercetin has an aqueous solubility of 0.4 mg/ml (room temperature, pH 3). [11] For the purpose of improving the solubility of these flavonoids, a variety of techniques has been used, including particle size reduction, [12][13][14] solid dispersions [14][15][16][17][18][19] and the formation of inclusion complexes. [10,14,[20][21][22] Among these methods, formulating as an amorphous solid dispersion is very attractive for the flavonoid compounds.…”