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With the development of alternatives to traditional fossil energy and the rise of wearable technology, flexible energy storage devices have attracted great attention. In this paper, a polyaniline/poly(acrylamide‐sodium acrylate copolymer) hydrogel (PASH) with high flexibility and excellent electrochemical properties for flexible electrodes is fabricated by freeze‐thaw‐shrink treatment of a highly water‐absorptive hydrogel, together with in‐situ polymerization of aniline at a low aniline concentration (0.1 mol L−1). The PASH exhibits a conductivity of 4.05 S m−1 and an elongation at break of 1245%. The freeze‐thaw‐shrink treatment greatly improves the electrochemical performance and stability of the conductive PASH. The area specific capacitance of PASH reaches 849 mF cm−2 and the capacitance maintains 89% after 1000 galvanostatic charge–discharge cycles. All the raw materials are conventional industrialized materials and no additional templating agent is needed during the entire synthesis process. This study provides a cost‐efficient approach for the fabrication of conductive polymer hydrogels, which has a broad application prospect in flexible energy storage electronic devices.

Results: The t 1/2 values of DOX/P(HB-HO) NPs and DOX/FA-PEG-P(HB-HO) NPs were 2.7-and 3.5-times higher than that of free DOX. No significant difference (p40.05) was found in C max between the NPs and free DOX. The T max values of the two NPs were prolonged from 0.25 to 1 h. The AUC 0-t values were 1.55-and 3.05-folds higher than that of free DOX, and MRT increased to 15.99 h for DOX/P(HB-HO) NPs and 25.14 h for DOX/FA-PEG-P(HB-HO) NPs. For DOX/FA-PEG-P(HB-HO) NPs, the DOX content in the tumors were 10.81-and 3.33-times higher than those for free DOX and DOX/P(HB-HO) NPs at 48 h, respectively. Discussion and conclusions: DOX/FA-PEG-P(HB-HO) NPs displayed reduced cardiac toxicity and improved bioavailability. Moreover, the NPs exhibited a significant extent of DOX accumulation in the tumors, thus suggesting that folate-targeted NPs could effectively transport into HeLa tumors with satisfying targeting.

In this study, a novel poly(3-hydroxybutyrate-co-3-hydroxyoctanoate) (P(HB-HO)) microparticle with an encapsulated antibiotic (azithromycin, AZI) was prepared by the electrospinning method. The resulting microparticles were evaluated for surface morphology, particle size, drug loading, encapsulation efficiency, in vitro drug-release and degradation. The in vitro cytotoxicity and in vivo pharmacokinetics were also studied. The sizes of microparticles showed a narrow monodisperse size distribution approximately from 3 to 30 µm. In vitro release experiments exhibited sustained release behavior. The results of in vitro degradation tests demonstrated that the mass loss of the P(HB-HO) microparticles was 9.6% and the morphology varied greatly within 24 weeks. P(HB-HO) showed no cytotoxicity to fibroblast when incubated with blank P(HB-HO) microparticles during the tests. The in vivo pharmacokinetic study demonstrated that the microparticles exhibited longer circulation properties than free AZI. It is suggested that novel AZI-loaded P(HB-HO) microparticles can be utilized as a biodegradable and biocompatible drug delivery system.

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Background and purpose: Bisphenol A (BPA) is a pervasive environmental toxicant with known adverse effects on human immune system and nervous system et al. Although, BPA is widely known to affect endocrine function in animals, the linkage between human exposure to BPA and human reproductive function is still not clearly clarified. Results: Systematic review of all articles about BPA and human reproductive function identified in SCOPUS and PubMed. Literature was summarized in narrative form and results are presented per category. Some observational surveys investigating the relationship between BPA exposure and human reproductive and/or endocrine function are inconsistent. Conclusion: Our review integrates the studies of BPA on reproductive and/or endocrine system in recent years, mainly explains the effects of BPA on these systems and provides the basis for subsequent studies on BPA.