Preparation and characterization of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) microspheres for controlled release of buprofezin

Zhang, Chan; Jia, Ruzhu; Dong, Yuefeng; Li, Zhao

doi:10.1007/s11356-019-04869-w

Cited by 11 publications

(3 citation statements)

References 23 publications

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“…According to the study by Zhang, 26 buprofezin microspheres were prepared by an O/W emulsion/solvent evaporation method with 15.68% drug‐loading and 78.00% EE, whereas chlorpyrifos microspheres using PLA as coating material showed 16.08% drug‐loading and 64.70% EE 27 . Drug‐loading and EE were influenced by many factors, such as drug chemical structure, property and type of organic solvents, ratio of aqueous phase and organic phase, elimination rate of organic solvents and properties of coating materials.…”

Section: Discussionmentioning

confidence: 99%

Preparation of a long‐lasting tablet of spinosad microspheres and its residual insecticidal efficacy against the yellow fever mosquito, Aedes aegypti (Diptera: Culicidae) larvae

Yu,

Li,

Wang

et al. 2024

Pest Management Science

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BACKGROUNDSTo provide a long‐lasting formulation for spinosad (SP) targeting larval stages of Aedes aegypti (Linnaeus) and others alike, a SP tablet was developed based on microspheres, using polylactic acid as inside coating material. The microspheres were encapsulated using polyethylene glycol and 1‐hexadecanol to form a sustained‐release SP tablet. Micromorphology, active ingredient loading, structure identification, photolysis resistance, and biological activity were evaluated in this report.RESULTS(1) SP microspheres have an average particle size of 6.16 ± 2.28 μm, low adhesion, and good dispersion as evaluated by scanning electron microscopy (SEM) and morphology; (2) The average active ingredient loading and encapsulation of SP microspheres were 32.80 ± 0.74% and 78.41 ± 2.22%, respectively; (3) The chemical structure of encapsulated SP was confirmed by FT‐IR and 1H‐NMR; (4) The photostability of the microspheres and the tablets were evaluated. The results showed that DT50 (time required to dissipate 50% of the mass originally present) of SP was 0.95 days in microspheres and 6.94 days in tablets. (5) The long‐term insecticidal activity of SP tablets was investigated, and the tablet had a long‐lasting activity against the mosquito larvae, showing 100% larval mortality for 63 days.CONCLUSIONSThe study provided a new long‐lasting formulation of SP which displayed good efficacy in the control of Ae. aegypti larvae.This article is protected by copyright. All rights reserved.

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Section: Discussionmentioning

confidence: 99%

Preparation of a long‐lasting tablet of spinosad microspheres and its residual insecticidal efficacy against the yellow fever mosquito, Aedes aegypti (Diptera: Culicidae) larvae

Yu,

Li,

Wang

et al. 2024

Pest Management Science

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“…preparation was optimized using Design Expert software (Version 13), The concentration of PLGA (X 1 ) and the concentration of PVA (X 2 ) were selected as independent variables based on preliminary studies, with loading content and nanoparticle shape (Y) as the response variable collectively. To depict the interrelationship between independent and response variables, the obtained data and model were fi tted using 3D surface plots [29].…”

Section: Nanoparticlesmentioning

confidence: 99%

PLGA Nanoparticles with Cannabidiol for Efficient and Durable Antibacterial Applications

Cheng,

Ma,

Tang

et al. 2023

J Biomed Res Environ Sci

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The Cannabidiol (CBD) are extensively used owing to their potent antibacterial effects. We developed CBD-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles using an emulsion process technology, resulting informing the PLGA@CBD nanoparticles. The emulsion parameters were optimized using three-dimensional surface plots. When scaled up under optimal conditions, the corresponding loading content efficiency were 16.51%. Compared with natural cannabidiol, the physically modified PLGA nanoparticles became smooth, round, and solid, improving their water solubility and bioavailability, realizing long-time antibacterial. Therefore, the nanoparticles showed better efficacy against Gram-positive bacteria. Our results confirm that the PLGA@CBD nanoparticles have been achieved as long-acting antibacterial delivery system, which improved the treatment efficiency.

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“…The surface morphology 18 and internal texture of gemcitabine hydrochloride micro particles were observed by scanning electron microscope at 3K magnification.…”

Section: Surface Topography (Sem)mentioning

confidence: 99%

Fabrication and Evaluation of Gemcitabine-loaded Alginate Microspheres: A Potential Approach for Treatment of Various Carcinomas

Hossain¹,

Chatterjee²,

Paria³

et al. 2022

IJPER

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Aim/background: Microspheres are spherical particles, having a core, having a particle size of 1µm to 1000µm. They are advantageous as compared to conventional dosage forms of drugs, in parameters like sustainability and control of drug release, drug protection, biodegradability, targeting ability and many more. Gemcitabine is a prodrug and is used in various carcinomas. Sodium Alginate and Ethyl Cellulose are used as polymers. The fabrication aims to sustain the drug release which can treat pancreatic, breast, ovarian and lung cancer. Materials and Methods: Microspheres have been made by Ionotropic Gelation method, Sodium alginate, Ethyl cellulose and Calcium chloride. Weighed quantity of drug and polymer were added to sodium alginate solution, which was then added drop wise to Calcium chloride solution under continuous stirring to procure spherical rigid microspheres. These were then subjected to various physicochemical characterizations and surface analysis. Results and Conclusion: Results have shown that by increasing the polymer concentration, entrapment efficiency and drug loading have also increased. Particle size, SEM and micromeritic evaluation have exhibited satisfactory results. The drug release studies depict that most of the batches have showed less than 10% release acid media so it protects the drug from the upper part of GI Tract. These attributes prove that microsphere technology, being a crucial novel drug delivery system can be very effective in reducing dose frequency, dose dumping and better patient compliance.

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Preparation and characterization of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) microspheres for controlled release of buprofezin

Cited by 11 publications

References 23 publications

Preparation of a long‐lasting tablet of spinosad microspheres and its residual insecticidal efficacy against the yellow fever mosquito, Aedes aegypti (Diptera: Culicidae) larvae

Preparation of a long‐lasting tablet of spinosad microspheres and its residual insecticidal efficacy against the yellow fever mosquito, Aedes aegypti (Diptera: Culicidae) larvae

PLGA Nanoparticles with Cannabidiol for Efficient and Durable Antibacterial Applications

Fabrication and Evaluation of Gemcitabine-loaded Alginate Microspheres: A Potential Approach for Treatment of Various Carcinomas

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