A new (aryloxyalkyl)adenine derivative Adeprophen (9-[2-(4-isopropylphenoxy)ethyl]adenine, VMA-99-82) has a strong antidepressant effect on the model of reserpine-induced depression in rats (single dose 4 mg/kg, intraperitoneally). This effect manifested in suppression of depression-like behavior in the Porsolt forced swimming test (shortening of immobility time and increase in immobility latency, number of jumping episodes, and time of active swimming) and sucrose consumption/preference test (increase in the consumption of 20% sucrose solution in g/100 g body weight and percentage of sucrose preference in relation to the total fluid preference). Adeprophen had a greater antidepressant effect than sertraline and fluoxetine, but was less potent than amitriptyline, imipramine, venlafaxine, and to a lesser extent to paroxetine.
Absract. A quantitative method has been developed for the phase analysis of magnesium alloys of the Mg-Zn-Al (MA2-1 and MA5) and Mg-Zn-Zr (MA14) systems based on the measurement of the lattice parameters of a solid solution, the use of Vegard’s law, and balance equations of chemical and phase composition. Examples of the application of the technique for assessing changes in the content of alloying elements in a solid solution and the number of intermetallic phases as a result of heat treatment of MA2-1 alloy are presented.
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